J Cancer 2020; 11(8):2360-2370. doi:10.7150/jca.39511 This issue

Research Paper

Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network

Daoqi Zhu1*, Meng Shao1*, Jiabin Yang1, Miao Fang1, Shiya Liu1, Dandan Lou1, Ruijiao Gao1, Ying Liu2, Aiwu Li2, Ying Lv2, Zhixian Mo1✉, Qin Fan1✉

1. School of Traditional Chinese Medicine, Southern Medical University, Guangdong Guangzhou, 510515, China
2. NanFang Hospital, Guangdong Guangzhou, 510515, China
*These authors contributed equally to this work

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Citation:
Zhu D, Shao M, Yang J, Fang M, Liu S, Lou D, Gao R, Liu Y, Li A, Lv Y, Mo Z, Fan Q. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J Cancer 2020; 11(8):2360-2370. doi:10.7150/jca.39511. Available from https://www.jcancer.org/v11p2360.htm

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Abstract

Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network.

Keywords: nasopharyngeal carcinoma, circRNA, tumor stem-like cells, radiosensitization, curcumin