J Cancer 2020; 11(8):2360-2370. doi:10.7150/jca.39511 This issue
1. School of Traditional Chinese Medicine, Southern Medical University, Guangdong Guangzhou, 510515, China
2. NanFang Hospital, Guangdong Guangzhou, 510515, China
*These authors contributed equally to this work
Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network.
Keywords: nasopharyngeal carcinoma, circRNA, tumor stem-like cells, radiosensitization, curcumin