1. School of Traditional Chinese Medicine, Southern Medical University, Guangdong Guangzhou, 510515, China 2. NanFang Hospital, Guangdong Guangzhou, 510515, China *These authors contributed equally to this work
✉ Corresponding authors: Qin Fan, School of Traditional Chinese Medicine, Southern Medical University, 1063 Shatai Road, Guangzhou, 510515, China. Tel: +86 13688859758; Email addresses: fqincom or Zhixian Mo, School of Traditional Chinese Medicine, Southern Medical University, 1063 Shatai Road, Guangzhou, 510515, China. Tel.: +86 20 61648261, Fax: +86 2061648244. Email address: cherrymocomMore
Citation:
Zhu D, Shao M, Yang J, Fang M, Liu S, Lou D, Gao R, Liu Y, Li A, Lv Y, Mo Z, Fan Q. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J Cancer 2020; 11(8):2360-2370. doi:10.7150/jca.39511. https://www.jcancer.org/v11p2360.htm
Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network.
Zhu, D., Shao, M., Yang, J., Fang, M., Liu, S., Lou, D., Gao, R., Liu, Y., Li, A., Lv, Y., Mo, Z., Fan, Q. (2020). Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. Journal of Cancer, 11(8), 2360-2370. https://doi.org/10.7150/jca.39511.
ACS
Zhu, D.; Shao, M.; Yang, J.; Fang, M.; Liu, S.; Lou, D.; Gao, R.; Liu, Y.; Li, A.; Lv, Y.; Mo, Z.; Fan, Q. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J. Cancer 2020, 11 (8), 2360-2370. DOI: 10.7150/jca.39511.
NLM
Zhu D, Shao M, Yang J, Fang M, Liu S, Lou D, Gao R, Liu Y, Li A, Lv Y, Mo Z, Fan Q. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J Cancer 2020; 11(8):2360-2370. doi:10.7150/jca.39511. https://www.jcancer.org/v11p2360.htm
CSE
Zhu D, Shao M, Yang J, Fang M, Liu S, Lou D, Gao R, Liu Y, Li A, Lv Y, Mo Z, Fan Q. 2020. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J Cancer. 11(8):2360-2370.
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