J Cancer 2020; 11(13):3965-3975. doi:10.7150/jca.42663

Review

The role and function of PPARγ in bladder cancer

Tianchen Peng1,5,*, Gang Wang2,3,4,*, Songtao Cheng1,5,*, Yaoyi Xiong1,5, Rui Cao6, Kaiyu Qian2,3,4, Lingao Ju2,3,4, Xinghuan Wang1,✉, Yu Xiao1,2,3,4,5,✉

1. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China
2. Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China
3. Human Genetics Resource Preservation Center of Wuhan University, Wuhan, China
4. Human Genetics Resource Preservation Center of Hubei Province, Wuhan, China
5. Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan, China
6. Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
*These authors contributed equally to this work.

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Citation:
Peng T, Wang G, Cheng S, Xiong Y, Cao R, Qian K, Ju L, Wang X, Xiao Y. The role and function of PPARγ in bladder cancer. J Cancer 2020; 11(13):3965-3975. doi:10.7150/jca.42663. Available from https://www.jcancer.org/v11p3965.htm

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Abstract

Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPARγ and various tumors. However, the expression and function of PPARγ in bladder cancer seem to be controversial. It has been demonstrated that PPARγ affects the occurrence and progression of bladder cancer by regulating proliferation, apoptosis, metastasis, and reactive oxygen species (ROS) and lipid metabolism, probably through PPARγ-SIRT1 feedback loops, the PI3K-Akt signaling pathway, and the WNT/β-catenin signaling pathway. Considering the frequent relapses after chemotherapy, some researchers have focused on the relationship between PPARγ and chemotherapy sensitivity in bladder cancer. Moreover, the feasibility of PPARγ ligands as potential therapeutic targets for bladder cancer has been uncovered. Taken together, this review summarizes the relevant literature and our findings to explore the complicated role and function of PPARγ in bladder cancer.

Keywords: PPARγ, bladder cancer, ROS metabolism, lipid metabolism, chemotherapy sensitivity, ligands