Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell

Fierros-Zárate, Geny; Olvera, Clarita; Salazar-Guerrero, Gustavo; Morales-Ortega, Ausencio; Reyna, Fernando; Hernández-Márquez, Eva; Guzmán-Olea, Eduardo; Burguete-García, Ana I.; Madrid-Marina, Vicente; Peralta-Zaragoza, Oscar; Chávez-Castillo, Marilú; Bermúdez-Morales, Víctor Hugo

doi:10.7150/jca.33527

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2020; 11(16):4754-4761. doi:10.7150/jca.33527 This issue Cite

Research Paper

Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell

Geny Fierros-Zárate¹, Clarita Olvera², Gustavo Salazar-Guerrero¹, Ausencio Morales-Ortega¹, Fernando Reyna¹, Eva Hernández-Márquez¹, Eduardo Guzmán-Olea^1,3, Ana I. Burguete-García¹, Vicente Madrid-Marina¹, Oscar Peralta-Zaragoza¹, Marilú Chávez-Castillo^1,4, Víctor Hugo Bermúdez-Morales^1✉

1. Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca Morelos, México.
2. Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca Morelos, México.
3. Catedrático Consejo Nacional de Ciencia y Tecnología (CONACYT). Instituto de Ciencias de la Salud (ICSA), Universidad Autónoma del Estado de Hidalgo (UAEH), México.
4. Universidad Tecnológica Emiliano Zapata de Morelos, UTEZ.

Citation:

Fierros-Zárate G, Olvera C, Salazar-Guerrero G, Morales-Ortega A, Reyna F, Hernández-Márquez E, Guzmán-Olea E, Burguete-García AI, Madrid-Marina V, Peralta-Zaragoza O, Chávez-Castillo M, Bermúdez-Morales VH. Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell. J Cancer 2020; 11(16):4754-4761. doi:10.7150/jca.33527. https://www.jcancer.org/v11p4754.htm

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Abstract

The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. The MAPK signaling pathway was activated, we detected the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Moreover, IFN-τ induced the expression of MHC Class I, MX and IP10 in the tumor cells and this response may be associated with the viral replication and with the anti-proliferative and the immunoregulatory effects of IFN-τ.

Keywords: IFN-τ, type 1 interferon, signal transducer, BMK-16/myc, tumor cells

Citation styles

APA

Fierros-Zárate, G., Olvera, C., Salazar-Guerrero, G., Morales-Ortega, A., Reyna, F., Hernández-Márquez, E., Guzmán-Olea, E., Burguete-García, A.I., Madrid-Marina, V., Peralta-Zaragoza, O., Chávez-Castillo, M., Bermúdez-Morales, V.H. (2020). Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell. Journal of Cancer, 11(16), 4754-4761. https://doi.org/10.7150/jca.33527.

ACS

Fierros-Zárate, G.; Olvera, C.; Salazar-Guerrero, G.; Morales-Ortega, A.; Reyna, F.; Hernández-Márquez, E.; Guzmán-Olea, E.; Burguete-García, A.I.; Madrid-Marina, V.; Peralta-Zaragoza, O.; Chávez-Castillo, M.; Bermúdez-Morales, V.H. Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell. J. Cancer 2020, 11 (16), 4754-4761. DOI: 10.7150/jca.33527.

NLM

CSE

Fierros-Zárate G, Olvera C, Salazar-Guerrero G, Morales-Ortega A, Reyna F, Hernández-Márquez E, Guzmán-Olea E, Burguete-García AI, Madrid-Marina V, Peralta-Zaragoza O, Chávez-Castillo M, Bermúdez-Morales VH. 2020. Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell. J Cancer. 11(16):4754-4761.

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