J Cancer 2020; 11(18):5395-5402. doi:10.7150/jca.41100 This issue

Research Paper

Circulating Levels of L1-cell Adhesion Molecule as a Serum Biomarker for Early Detection of Gastric Cancer and Esophagogastric Junction Adenocarcinoma

Ling-Yu Chu1*, Yu-Hui Peng2*, Tian Yang3*, Wang-Kai Fang1, Chao-Qun Hong4, Li-Sheng Huang5, Li-Yan Xu6, En-Min Li1, Yi-Wei Xu2✉, Jian-Jun Xie1✉

1. Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, China.
2. Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University Medical College, Shantou, China.
3. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
4. Department of Oncological Laboratory Research, the Cancer Hospital of Shantou University Medical College, Shantou, China.
5. Department of Radiation Oncology, the Cancer Hospital of Shantou University Medical College, Shantou, China.
6. Institute of Oncologic Pathology, Shantou University Medical College, Shantou, China.
*These authors contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Chu LY, Peng YH, Yang T, Fang WK, Hong CQ, Huang LS, Xu LY, Li EM, Xu YW, Xie JJ. Circulating Levels of L1-cell Adhesion Molecule as a Serum Biomarker for Early Detection of Gastric Cancer and Esophagogastric Junction Adenocarcinoma. J Cancer 2020; 11(18):5395-5402. doi:10.7150/jca.41100. Available from https://www.jcancer.org/v11p5395.htm

File import instruction

Abstract

Background: Low serum L1 cell adhesion molecule (L1CAM) has been found in several malignant tumors. Here, we aimed to evaluate the diagnostic potential for serum L1CAM in patients with gastric cancers (GC) and esophagogastric junction adenocarcinoma (EJA).

Methods: Enzyme-linked immunosorbent assay (ELISA) was carried out to detect L1CAM level in sera of 148 GC patients, 59 EJA patients and 148 healthy controls. Receiver operating characteristics (ROC) was employed to evaluate diagnostic accuracy.

Results: The concentrations of serum L1CAM were significantly lower in GC and EJA than those in healthy controls (P<0.001). Detection of L1CAM provided a sensitivity of 83.1%, a specificity of 62.2%, and an area under the curve (AUC) of 0.769 (95% CI: 0.715-0.823) in diagnosing GC, and a sensitivity of 66.1%, a specificity of 62.2%, and an AUC of 0.672 (95% CI: 0.590-0.755) in diagnosing EJA. Similar results were observed in the diagnosis of early-stage GC (0.681 (95%CI: 0.596-0.766)) and early-stage EJA (0.674 (95%CI: 0.528-0.820)). Analysis of clinical data showed that the levels of L1CAM were significantly associated with lymph node metastasis in GC (P<0.05).

Conclusions: Our study showed that serum L1CAM might be a diagnostic biomarker for GC and EJA.

Keywords: gastric cancer, esophagogastric junction cancer, L1CAM, serum biomarker, early diagnosis