J Cancer 2020; 11(20):6019-6024. doi:10.7150/jca.47026 This issue

Research Paper

The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas

Nicusor Iftimia1✉#, Aditi Sahu2#, Miguel Cordova2, Gopi Maguluri1, Melissa Gill3, Christi Alessi-Fox4, Salvador Gonzalez5, Cristian Navarrete-Dechent6, Ashfaq Marghoob2, Chih-Shan J. Chen2*, Milind Rajadhyaksha2*

1. Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, MA, USA.
2. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3. Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
4. Caliber Imaging and Diagnostics, Rochester, NY, USA.
5. Alcala University, Madrid, Spain.
6. Pontificia Universidad Catolica De Chile, Santiago, Chile.
#Equal contributions as main authors.
*Equal contribution as senior authors.

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Citation:
Iftimia N, Sahu A, Cordova M, Maguluri G, Gill M, Alessi-Fox C, Gonzalez S, Navarrete-Dechent C, Marghoob A, Chen CSJ, Rajadhyaksha M. The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas. J Cancer 2020; 11(20):6019-6024. doi:10.7150/jca.47026. Available from https://www.jcancer.org/v11p6019.htm

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Abstract

The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be used. Optical imaging may be used to guide diagnosis and margin assessment at the bedside, and potentially facilitate non-surgical management, along with long-term monitoring of treatment response. Noninvasive imaging may also complement minimally invasive treatments and help further reduce morbidity. In this paper, we highlight the current state of an integrated RCM/OCT imaging approach for diagnosis and triage of BCCs, as well as for assessing margins, which therefore may be ultimately used for guiding therapy.

Keywords: basal cell carcinomas, invasive non-surgical treatments, reflectance confocal microscopy, optical coherence tomography