Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers

Zhu, Dong-Li; Tuo, Xiao-Mei; Rong, Yu; Zhang, Kun; Guo, Yan

doi:10.7150/jca.44727



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2020; 11(24):7264-7275. doi:10.7150/jca.44727 This issue Cite

Review

Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers

Dong-Li Zhu^1,2,3, Xiao-Mei Tuo², Yu Rong², Kun Zhang^1✉, Yan Guo^1,2✉

1. Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Trauma Surgery, Honghui Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.
2. Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China, 710054.
3. Research institute of Xi'an Jiaotong University, Hangzhou, Zhejiang, P. R. China, 311215.

Citation:

Zhu DL, Tuo XM, Rong Y, Zhang K, Guo Y. Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers. J Cancer 2020; 11(24):7264-7275. doi:10.7150/jca.44727. https://www.jcancer.org/v11p7264.htm

Other styles

Abstract

Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patterns, displaying low survival and high frequency of recurrence. In an era of personalized medicine, novel therapeutic approaches with greater efficacy for these cancers represent an unmet need. One of the actionable signaling pathways is the fibroblast growth factor receptor (FGFR) signaling pathway. Several mutations and alterations in FGF/FGFR family members have been reported in human cancers. FGF/FGFR signaling pathway has become a new target for cancer therapy. This review will summarize the role of FGFR pathway and the genetic alterations of the FGF/FGFR related to female reproductive system cancer. We will describe the available inhibitors of FGFR pathway for potential treatment of female reproductive system cancer. Furthermore, we will discuss FGFR-targeted therapies under clinical development for treatment of female reproductive system cancer.

Keywords: Fibroblast growth factor, Fibroblast growth factor receptor, Genetic variations, Therapeutic targets, Female reproductive system cancer

Citation styles

APA

Zhu, D.L., Tuo, X.M., Rong, Y., Zhang, K., Guo, Y. (2020). Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers. Journal of Cancer, 11(24), 7264-7275. https://doi.org/10.7150/jca.44727.

ACS

Zhu, D.L.; Tuo, X.M.; Rong, Y.; Zhang, K.; Guo, Y. Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers. J. Cancer 2020, 11 (24), 7264-7275. DOI: 10.7150/jca.44727.

NLM

CSE

Zhu DL, Tuo XM, Rong Y, Zhang K, Guo Y. 2020. Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers. J Cancer. 11(24):7264-7275.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.