USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP

Sun, Hongze; Wang, Rangrang; Liu, Yuan; Mei, Haitao; Liu, Xueni; Peng, Zhihai

doi:10.7150/jca.52158

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(8):2317-2325. doi:10.7150/jca.52158 This issue Cite

Research Paper

USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP

Hongze Sun^1,2#, Rangrang Wang^1#, Yuan Liu^1#, Haitao Mei¹, Xueni Liu^1✉, Zhihai Peng^1,3✉

1. Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
2. Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
3. Department of General Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
#These authors contributed equally to this work.

Citation:

Sun H, Wang R, Liu Y, Mei H, Liu X, Peng Z. USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP. J Cancer 2021; 12(8):2317-2325. doi:10.7150/jca.52158. https://www.jcancer.org/v12p2317.htm

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Abstract

Chemotherapy plays an important role in the treatment of patients with colorectal cancer (CRC). However, the resistance to chemotherapy severely affects the prognosis of CRC patients and the mechanisms are still poorly understood. Our study investigated the role of ubiquitin-specific protease 11 (USP11) in CRC chemotherapy and found that USP11 could induce resistance to 5-fluorouracil by activating autophagy. A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK/Akt/mTOR pathway via stabilizing valosin-containing protein (VCP). Overall, our study demonstrated that USP11 might be valuable to predict the chemotherapeutic sensitivity and improve the prognosis of CRC patients.

Keywords: USP11, VCP, colorectal cancer, 5-fluorouracil, chemotherapy resistance

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APA

Sun, H., Wang, R., Liu, Y., Mei, H., Liu, X., Peng, Z. (2021). USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP. Journal of Cancer, 12(8), 2317-2325. https://doi.org/10.7150/jca.52158.

ACS

Sun, H.; Wang, R.; Liu, Y.; Mei, H.; Liu, X.; Peng, Z. USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP. J. Cancer 2021, 12 (8), 2317-2325. DOI: 10.7150/jca.52158.

NLM

CSE

Sun H, Wang R, Liu Y, Mei H, Liu X, Peng Z. 2021. USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP. J Cancer. 12(8):2317-2325.

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