Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer

Lv, Liting; Liang, Xiao; Wu, Dan; Wang, Feng; Zhang, Yan; Cang, Hui; Deng, Xiongwei; Li, Mei

doi:10.7150/jca.51433

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J Cancer 2021; 12(8):2385-2394. doi:10.7150/jca.51433 This issue Cite

Research Paper

Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer

Liting Lv^1*, Xiao Liang^2*, Dan Wu², Feng Wang¹, Yan Zhang¹, Hui Cang³, Xiongwei Deng^4✉, Mei Li^1✉

1. Department of oncology, Affiliated hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
2. Department of oncology, Jiangyin People's Hospital, Wuxi, 214400, Jiangsu Province, China.
3. Department of gastroenterology, Jiangyin People's Hospital, Wuxi, 214400, Jiangsu Province, China.
4. Department of orthopedics, Jiangyin People's Hospital, Wuxi, 214400, Jiangsu Province, China.
* These authors contributed equally to this study.

Citation:

Lv L, Liang X, Wu D, Wang F, Zhang Y, Cang H, Deng X, Li M. Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer. J Cancer 2021; 12(8):2385-2394. doi:10.7150/jca.51433. https://www.jcancer.org/v12p2385.htm

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Abstract

Background: The prognosis of early cardia cancer and non-cardia cancer is still controversial. It is difficult to collect a large number of cases with complete information in clinical practice. Our study was aimed to identify the differences in clinicopathological characteristics and outcomes of early cardia gastric cancer and non-cardia gastric cancer.

Methods: All cases analyzed were from Surveillance, Epidemiology, and End Results database. The data of the patients with early gastric cancer from 2004 to 2010 was retrospectively analyzed. Patients were distributed to cardia cancer group and non-cardia cancer group. Univariate and multivariate analyses were performed to examine differences between groups. The competitive risk model was made to compare the association with cardia cancer and non-cardia cancer about the causes of death. Propensity score matching (PSM) was performed to reduce the bias.

Results: We found that cardia cancer was more common in male patients and the White than that in non-cardia cancer at early stage, signet ring cell carcinoma was more common in non-cardia cancer, and the differentiation of non-cardia cancer was worse. Univariate analysis showed that age, marital status, race, tumor location, histology, grade, stage, and operation or not can determine the prognosis. And the prognosis of patients with cardia cancer was worse than that of non-cardia cancer, according to lymph node metastasis and the depth of tumor invasion. Multivariate analysis showed cardia cancer was an independent prognostic factor for poor prognosis. After PSM, cardia cancer still exhibited poor prognosis.

Conclusions: At early stage, cardia cancer had a poor prognosis compared with non-cardia cancer. The prevention and treatment of early cardia cancer need to be seriously treated.

Keywords: early gastric cancer, cardia cancer, non-cardia caner, prognosis, propensity score matching.

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APA

Lv, L., Liang, X., Wu, D., Wang, F., Zhang, Y., Cang, H., Deng, X., Li, M. (2021). Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer. Journal of Cancer, 12(8), 2385-2394. https://doi.org/10.7150/jca.51433.

ACS

Lv, L.; Liang, X.; Wu, D.; Wang, F.; Zhang, Y.; Cang, H.; Deng, X.; Li, M. Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer. J. Cancer 2021, 12 (8), 2385-2394. DOI: 10.7150/jca.51433.

NLM

CSE

Lv L, Liang X, Wu D, Wang F, Zhang Y, Cang H, Deng X, Li M. 2021. Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer. J Cancer. 12(8):2385-2394.

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