Exosome in Hepatocellular Carcinoma: an update

Chen, Wei; Mao, Yinqi; Liu, Chenbin; Wu, Han; Chen, Shuying

doi:10.7150/jca.54566

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(9):2526-2536. doi:10.7150/jca.54566 This issue Cite

Review

Exosome in Hepatocellular Carcinoma: an update

Wei Chen¹, Yinqi Mao¹, Chenbin Liu¹, Han Wu¹, Shuying Chen^2✉

1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
2. Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

Citation:

Chen W, Mao Y, Liu C, Wu H, Chen S. Exosome in Hepatocellular Carcinoma: an update. J Cancer 2021; 12(9):2526-2536. doi:10.7150/jca.54566. https://www.jcancer.org/v12p2526.htm

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Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor in the digestive tract with limited therapeutic choices. Intercellular communication among cancer cells and their microenvironment is crucial to disease progression. Exosomes are extracellular vesicles secreted by multiple types of cells into the extracellular space, which contain a variety of active components of secretory cells, including lipids, proteins, RNA and DNA. This vesicle structure involves in the exchange of materials and information between cells and plays an important role in the development of many diseases. Studies have shown that exosomes participate in the communication between HCC cells and non-HCC cells and regulate the occurrence and development of hepatocellular carcinoma. Therefore, exosomes may be specific biomarkers for early diagnosis and metastasis of HCC, which are also potential targets for the treatment of HCC. This review summarizes the characteristic, types and biological functions of exosomes and discusses their research progress and application prospects in the diagnosis and treatment of HCC.

Keywords: hepatocellular carcinoma, exosome, biological function, biomarker, therapeutic target

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APA

Chen, W., Mao, Y., Liu, C., Wu, H., Chen, S. (2021). Exosome in Hepatocellular Carcinoma: an update. Journal of Cancer, 12(9), 2526-2536. https://doi.org/10.7150/jca.54566.

ACS

Chen, W.; Mao, Y.; Liu, C.; Wu, H.; Chen, S. Exosome in Hepatocellular Carcinoma: an update. J. Cancer 2021, 12 (9), 2526-2536. DOI: 10.7150/jca.54566.

NLM

Chen W, Mao Y, Liu C, Wu H, Chen S. Exosome in Hepatocellular Carcinoma: an update. J Cancer 2021; 12(9):2526-2536. doi:10.7150/jca.54566. https://www.jcancer.org/v12p2526.htm

CSE

Chen W, Mao Y, Liu C, Wu H, Chen S. 2021. Exosome in Hepatocellular Carcinoma: an update. J Cancer. 12(9):2526-2536.

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