CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway

Zhang, Xiao; Zhang, Xiaofei; Mao, Tiebo; Xu, Haiyan; Cui, Jiujie; Lin, Hechun; Wang, Liwei

doi:10.7150/jca.54482

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International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(10):2797-2806. doi:10.7150/jca.54482 This issue Cite

Research Paper

CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway

Xiao Zhang^*, Xiaofei Zhang^*, Tiebo Mao, Haiyan Xu, Jiujie Cui^✉, Hechun Lin^✉, Liwei Wang^✉

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
* These authors contributed equally to this work.

✉ Corresponding authors: Liwei Wang, M.D. & Phd, liweiwangedu.cn, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 More

Citation:

Zhang X, Zhang X, Mao T, Xu H, Cui J, Lin H, Wang L. CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. J Cancer 2021; 12(10):2797-2806. doi:10.7150/jca.54482. https://www.jcancer.org/v12p2797.htm

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Abstract

Pancreatic cancer is one of the most aggressive tumors with poor prognosis and new targetable therapies are urgently required. CSE1L (chromosome segregation 1 like) is thought to play an important role in tumorigenesis and acts as a cancer therapeutic target. However, the biological function and the underlying mechanism of CSE1L in pancreatic cancer are still not fully explicit. In the present study, we found that high CSE1L expression was related to a worse prognosis in patients with pancreatic cancer according to data from the Cancer Genome Atlas (TCGA) database. Additionally, we found that CSE1L knockdown inhibited the proliferation of pancreatic cancer cells and promoted apoptosis, while CSE1L overexpression demonstrated the opposite phenomenon. Furthermore, we discovered that CSE1L might regulate pancreatic cancer proliferation through AKT signaling pathway. In summary, we reveal that CSE1L plays a crucial role in tumor growth and may serve as a potential prognostic and therapeutic target for pancreatic cancer.

Keywords: pancreatic cancer, CSE1L, proliferation, AKT/mTOR signaling pathway.

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APA

Zhang, X., Zhang, X., Mao, T., Xu, H., Cui, J., Lin, H., Wang, L. (2021). CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. Journal of Cancer, 12(10), 2797-2806. https://doi.org/10.7150/jca.54482.

ACS

Zhang, X.; Zhang, X.; Mao, T.; Xu, H.; Cui, J.; Lin, H.; Wang, L. CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. J. Cancer 2021, 12 (10), 2797-2806. DOI: 10.7150/jca.54482.

NLM

CSE

Zhang X, Zhang X, Mao T, Xu H, Cui J, Lin H, Wang L. 2021. CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. J Cancer. 12(10):2797-2806.

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