ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2021; 12(16):5066-5075. doi:10.7150/jca.45648 This issue Cite
Research Paper
Evaluation of the value of Preoperative Sialic Acid Levels in Diagnosis and Localization of Urothelial Tumors
1. Department of Urology, Qilu Hospital of Shandong University, Wenhuaxi Road 107#, Jinan, 250012, P.R. China.
2. Department of Urology, Second Traditional Chinese Medicine Hospital of Dezhou City, Zhongxing Road 245#, Dezhou , 253500, P.R. China.
*These authors contributed equally to the manuscript.
Abstract
Objective: To explore SA levels in the serum of urothelial tumor patients and their correlation with clinical pathological features and localization.
Materials and Methods: Our research retrospectively collected data from 591 patients with urothelial tumors between July 2014 and April 2018. The SA levels in the serum of urothelial tumor patients and their correlation with clinical pathological features and localization were investigated. Univariate and multivariate logistic regression analyses were further performed to identify independent associations.
Results: The levels of SA were significantly associated with the malignant degree (tumor grade and infiltration) of bladder cancer and tumor localization (all p < 0.05). The multivariate logistic regression model showed that SA levels were independently associated with the presence of high-grade urothelial carcinoma (BUC: HR = 1.941, UTUC: HR = 3.820, all p <0.05) and upper urinary tract urothelial carcinoma (HR = 2.047, p < 0.05). Finally, we validated the diagnosis and localization value of SA in an independent cohort from another institutions.
Conclusions: Elevated serum SA levels are an independent predictor of high-grade urothelial carcinoma and upper urinary tract urothelial carcinoma, indicating that SA levels may be a potential biomarker for the diagnosis, prognosis and localization of urothelial tumors.
Keywords: sialic acid, urothelial tumor, diagnosis, localization
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