J Cancer 2021; 12(18):5375-5384. doi:10.7150/jca.52310

Research Paper

MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma

Alessio Giubellino1✉, Christopher J. Ricketts2, Vanessa Moreno1, W. Marston Linehan2, Maria J. Merino1✉

1. Translational Surgical Pathology, Laboratory of Pathology, National Institutes of health, Bethesda, MD
2. Urologic Oncology Branch National Cancer Institute, National Institutes of health, Bethesda, MD

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Citation:
Giubellino A, Ricketts CJ, Moreno V, Linehan WM, Merino MJ. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. J Cancer 2021; 12(18):5375-5384. doi:10.7150/jca.52310. Available from https://www.jcancer.org/v12p5375.htm

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Abstract

Intratumoral heterogeneity (IH) has been recently described as an important contributor to tumor growth through a branched rather than a linear pattern of tumor evolution for renal cell carcinoma. As to whether the miRNA profiling of the different and heterogeneous areas is the same or not, it is not known. This study analyzed the differences and similarities of the miRNA profiles in histologically distinct regions within several RCC tumors. The observed differences may have great implications for the development of predictive biomarkers and the identification of druggable targets with improvement of combinatorial therapeutic approaches for the effective treatment of kidney cancer, as well as for the identification of circulating malignant cells that can be useful to detect tumor recurrences.

Keywords: MicroRNA, Clear cell renal cell carcinoma, ccRCC, Intratumoral heterogeneity, Tumor histology, Heterogeneous tumor morphology