J Cancer
2021; 12(18):5375-5384.
doi:10.7150/jca.52310 This issueCite
Research Paper
MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma
Alessio Giubellino1✉, Christopher J. Ricketts2, Vanessa Moreno1, W. Marston Linehan2, Maria J. Merino1✉
1. Translational Surgical Pathology, Laboratory of Pathology, National Institutes of health, Bethesda, MD 2. Urologic Oncology Branch National Cancer Institute, National Institutes of health, Bethesda, MD
✉ Corresponding authors: Maria J Merino. MD, Translational Surgical Pathology- Lab of Pathology, NCI, Building 10, Room 3S235C, Bethesda, MD 20892. mjmerinonih.gov. Alessio Giubellino, MD PhD. Current address: University of Minnesota, Department of Laboratory Medicine and Pathology, 420 Delaware St. SE, C516 Mayo, Minneapolis, MN, 55455. Email: agiubelleduMore
Citation:
Giubellino A, Ricketts CJ, Moreno V, Linehan WM, Merino MJ. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. J Cancer 2021; 12(18):5375-5384. doi:10.7150/jca.52310. https://www.jcancer.org/v12p5375.htm
Intratumoral heterogeneity (IH) has been recently described as an important contributor to tumor growth through a branched rather than a linear pattern of tumor evolution for renal cell carcinoma. As to whether the miRNA profiling of the different and heterogeneous areas is the same or not, it is not known. This study analyzed the differences and similarities of the miRNA profiles in histologically distinct regions within several RCC tumors. The observed differences may have great implications for the development of predictive biomarkers and the identification of druggable targets with improvement of combinatorial therapeutic approaches for the effective treatment of kidney cancer, as well as for the identification of circulating malignant cells that can be useful to detect tumor recurrences.
Giubellino, A., Ricketts, C.J., Moreno, V., Linehan, W.M., Merino, M.J. (2021). MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. Journal of Cancer, 12(18), 5375-5384. https://doi.org/10.7150/jca.52310.
ACS
Giubellino, A.; Ricketts, C.J.; Moreno, V.; Linehan, W.M.; Merino, M.J. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. J. Cancer 2021, 12 (18), 5375-5384. DOI: 10.7150/jca.52310.
NLM
Giubellino A, Ricketts CJ, Moreno V, Linehan WM, Merino MJ. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. J Cancer 2021; 12(18):5375-5384. doi:10.7150/jca.52310. https://www.jcancer.org/v12p5375.htm
CSE
Giubellino A, Ricketts CJ, Moreno V, Linehan WM, Merino MJ. 2021. MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma. J Cancer. 12(18):5375-5384.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Global reach, higher impact
