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Volume 12 (18); 2021

Research Papers

MicroRNA Profiling of Morphologically Heterogeneous Clear Cell Renal Cell Carcinoma
Alessio Giubellino, Christopher J. Ricketts, Vanessa Moreno, W. Marston Linehan, Maria J. Merino
J. Cancer 2021; 12(18): 5375-5384. doi:10.7150/jca.52310
Abstract Full text PDF PubMed PMC

Mutation SVCT2 promotes cell proliferation, invasion and migration in colorectal cancer
Sang-Soo Park, Yea Seong Ryu, Dong-In Koh, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Mi Jin Kim, Do Yeon Kim, Jun Ki Hong, Eun Ho Kim, Hong-Rae Jeong, Yoon Sun Park, Joseph Kim, Dong Min Kim, Hyeseon Yun, Joo-Yeon Shin, Dong-Hoon Jin
J. Cancer 2021; 12(18): 5385-5393. doi:10.7150/jca.57463
Abstract Full text PDF PubMed PMC

MiR-301a-5p/SCIN promotes gastric cancer progression via regulating STAT3 and NF-κB signaling
Yingying Huang, Xiaoxiao Du, Xiangliu Chen, Chuanzhi Chen, Haiyong Wang, Yan Yang, Lisong Teng
J. Cancer 2021; 12(18): 5394-5403. doi:10.7150/jca.59747
Abstract Full text PDF PubMed PMC

PSD3 is an oncogene that promotes proliferation, migration, invasion, and G1/S transition while inhibits apoptotic in papillary thyroid cancer
Lingli Jin, Danni Zheng, Adheesh Bhandari, Danxiang Chen, Erjie Xia, Yaoyao Guan, Jialiang Wen, Ouchen Wang
J. Cancer 2021; 12(18): 5413-5422. doi:10.7150/jca.60885
Abstract Full text PDF PubMed PMC

Serial surveillance by circulating tumor DNA profiling after chimeric antigen receptor T therapy for the guidance of r/r diffuse large B cell lymphoma precise treatment
Linghui Zhou, Houli Zhao, Yang Shao, Xin Chen, Ruimin Hong, Linqin Wang, Fang Ni, Arnon Nagler, Yongxian Hu, He Huang
J. Cancer 2021; 12(18): 5423-5431. doi:10.7150/jca.60390
Abstract Full text PDF PubMed PMC

GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer
Sonia Brun, Jean-Marc Pascussi, Elena Patricia Gifu, Eloïne Bestion, Zuzana Macek-Jilkova, Guanxiong Wang, Firas Bassissi, Soraya Mezouar, Jérôme Courcambeck, Philippe Merle, Thomas Decaens, Julie Pannequin, Philippe Halfon, Claude Caron de Fromentel
J. Cancer 2021; 12(18): 5432-5438. doi:10.7150/jca.58533
Abstract Full text PDF PubMed PMC

SLC34A2 Up-regulation And SLC4A4 Down-regulation Correlates With Invasion, Metastasis, And The MAPK Signaling Pathway In Papillary Thyroid Carcinomas
Fengyan Huang, Haitao Wang, Juan Xiao, Chunchun Shao, Yong Zhou, Wei Cong, Maosong Gong, Jingfu Sun, Liqun Shan, Zhanyu Hao, Lihua Wang, Shouluan Ding, Zhigang Yu, Jianing Liu, Hongying Jia
J. Cancer 2021; 12(18): 5439-5453. doi:10.7150/jca.56730
Abstract Full text PDF PubMed PMC

The Expression of CLDN6 in Hepatocellular Carcinoma Tissue and the Effects of CLDN6 on Biological Phenotypes of Hepatocellular Carcinoma Cells
Yan Lu, Qihua Dang, Yin Bo, Xuejin Su, Liping Wang, Jiaqi Sun, Junyuan Wei, Chengshi Quan, Yanru Li
J. Cancer 2021; 12(18): 5454-5463. doi:10.7150/jca.55727
Abstract Full text PDF PubMed PMC

Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells
Kun Cao, Yuanyuan Chen, Songyun Zhao, Yijuan Huang, Tingting Liu, Hu Liu, Bailong Li, Jianguo Cui, Jianming Cai, Chong Bai, Yanyong Yang, Fu Gao
J. Cancer 2021; 12(18): 5464-5472. doi:10.7150/jca.53173
Abstract Full text PDF PubMed PMC

DNA methylation mediated down-regulation of ANGPTL4 promotes colorectal cancer metastasis by activating the ERK pathway
Kunning Zhang, Zhiwei Zhai, Sanshui Yu, Yu Tao
J. Cancer 2021; 12(18): 5473-5485. doi:10.7150/jca.52338
Abstract Full text PDF PubMed PMC

PHLDA1 Modulates the Endoplasmic Reticulum Stress Response and is required for Resistance to Oxidative Stress-induced Cell Death in Human Ovarian Cancer Cells
Jing Xu, Gang Bi, Qingya Luo, Yi Liu, Tao Liu, Lanfang Li, Qi Zeng, Qien Wang, Yufeng Wang, Jianhua Yu, Ping Yi
J. Cancer 2021; 12(18): 5486-5493. doi:10.7150/jca.45262
Abstract Full text PDF PubMed PMC

A practical update on the epidemiology and risk factors for the emergence and mortality of bloodstream infections from real-world data of 3014 hematological malignancy patients receiving chemotherapy
Shaozhen Chen, Kangni Lin, Qian Li, Xiaofeng Luo, Min Xiao, Minmin Chen, Haojie Zhu, Yongquan Chen, Xueqiong Wu, Yanling Zeng, Yuxin Zhang, Issa Hajji Ally, Jingjing Xu, Jinhua Ren, Zhizhe Chen, Jianda Hu, Ting Yang
J. Cancer 2021; 12(18): 5494-5505. doi:10.7150/jca.50802
Abstract Full text PDF PubMed PMC

Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort
Yi-Zhen Gong, Hui Ma, Guo-Tian Ruan, Li-Chen Zhu, Xi-Wen Liao, Shuai Wang, Ling Yan, Wei Huang, Ke-Tuan Huang, Hailun Xie, Guang-Zhi Zhu, Xiang-Kun Wang, Cun Liao, Feng Gao
J. Cancer 2021; 12(18): 5506-5518. doi:10.7150/jca.51524
Abstract Full text PDF PubMed PMC

Suppression Of Aberrant Activation Of NF-κB Pathway In Drug-resistant Leukemia Stem Cells Contributes To Parthenolide-potentiated Reversal Of Drug Resistance In Leukemia
Juan Yi, Li Wang, Xiao-Yan Wang, Jing Sun, Xiao-Yang Yin, Jin-Xia Hou, Jing Chen, Bei Xie, Hu-Lai Wei
J. Cancer 2021; 12(18): 5519-5529. doi:10.7150/jca.52641
Abstract Full text PDF PubMed PMC

High Expression of RhoF Predicts Worse Overall Survival: A Potential Therapeutic Target for non-M3 Acute Myeloid Leukemia
Yue Hou, Jie Zi, Zheng Ge
J. Cancer 2021; 12(18): 5530-5542. doi:10.7150/jca.52648
Abstract Full text PDF PubMed PMC

HOTAIR promotes gefitinib resistance through modification of EZH2 and silencing p16 and p21 in non-small cell lung cancer
Weiting Li, Yongwen Li, Hongbing Zhang, Minghui Liu, Hao Gong, Yin Yuan, Ruifeng Shi, Zihe Zhang, Chao Liu, Chen Chen, Hongyu Liu, Jun Chen
J. Cancer 2021; 12(18): 5562-5572. doi:10.7150/jca.56093
Abstract Full text PDF PubMed PMC

Prediction Model of Lymph Node Metastasis Risk in Elderly Patients with Early Gastric Cancer before Endoscopic Resection: A Retrospective Analysis Based on International Multicenter Data
Siwei Pan, Wen An, Yuen Tan, Qingchuan Chen, Pengfei Liu, Huimian Xu
J. Cancer 2021; 12(18): 5583-5592. doi:10.7150/jca.56702
Abstract Full text PDF PubMed PMC

The Differential Antitumor Activity of 5-Aza-2'-deoxycytidine in Prostate Cancer DU145, 22RV1, and LNCaP Cells
Huiying Cheng, Sijie Tang, Xueqi Lian, Hong Meng, Xiang Gu, Jiajia Jiang, Xiaohua Li
J. Cancer 2021; 12(18): 5593-5604. doi:10.7150/jca.56709
Abstract Full text PDF PubMed PMC

Comprehensive analysis of Transcription Factors identified novel prognostic biomarker in human bladder cancer
Yihao Liao, Xuanxuan Zou, Keke Wang, Youzhi Wang, Miaomiao Wang, Tao Guo, Boqiang Zhong, Ning Jiang
J. Cancer 2021; 12(18): 5605-5621. doi:10.7150/jca.58484
Abstract Full text PDF PubMed PMC

NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells
Hao Hu, Wuqiang Chen, Shuo Zhang, Yuzheng Xue, Youzhao He, Yuanlong Gu
J. Cancer 2021; 12(18): 5622-5632. doi:10.7150/jca.58824
Abstract Full text PDF PubMed PMC

Long non-coding RNA RP4-694A7.2 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the Regulation of PSAT1
Yaoxin Fan, Lin Wang, Yang Ding, Qiuju Sheng, Chong Zhang, Yanwei Li, Chao Han, Bingchao Lu, Xiaoguang Dou
J. Cancer 2021; 12(18): 5633-5643. doi:10.7150/jca.59348
Abstract Full text PDF PubMed PMC

The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study
Qing Chen, Xiaohui Chen, Lei Zhou, Fancheng Chen, Annan Hu, Ketao Wang, Haifeng Liang, Libo Jiang, Xilei Li, Jian Dong
J. Cancer 2021; 12(18): 5644-5653. doi:10.7150/jca.60821
Abstract Full text PDF PubMed PMC

A Luminacin D Analog HL142 Inhibits Ovarian Tumor Growth and Metastasis by Reversing EMT and Attenuating the TGFβ and FAK Pathways
Baojin Wang, Hanxuan Li, Xinxin Zhao, Wenjing Zhang, Guannan Zhao, Zhongzhi Wu, Ruitao Zhang, Peixin Dong, Hidemichi Watari, Gabor Tigyi, Wei Li, Junming Yue
J. Cancer 2021; 12(18): 5654-5663. doi:10.7150/jca.61066
Abstract Full text PDF PubMed PMC

Muscle-Related Parameters as Determinants of Survival in Patients with Stage I-III Gastric Cancer Undergoing Gastrectomy
Soomin An, Wankyu Eo, Youn-Jung Kim
J. Cancer 2021; 12(18): 5664-5673. doi:10.7150/jca.61199
Abstract Full text PDF PubMed PMC

Disregulations of PURPL and MiR-338-3p Could Serve As Prognosis Biomarkers for Epithelial Ovarian Cancer
Ruitao Zhang, Tingting He, Huirong Shi, Cao Yuan, Feng Wei, Zheying Liu, Wenwen Wang
J. Cancer 2021; 12(18): 5674-5680. doi:10.7150/jca.61327
Abstract Full text PDF PubMed PMC

When to apply immune checkpoint inhibitor in patients with refractory advanced gastric cancer
Hongsik Kim, Hana Kim, Minsang Lee, Minsuk Kwon, Jung Yong Hong, Jeeyun Lee, Ho Yeong Lim, Won Ki Kang, Seung Tae Kim
J. Cancer 2021; 12(18): 5681-5686. doi:10.7150/jca.62853
Abstract Full text PDF PubMed PMC

Treatment with Granulocyte-colony Stimulating Factor (G-CSF) is not associated with Increased Risk of Brain Metastasis in Patients with De Novo Stage IV Breast Cancer
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
J. Cancer 2021; 12(18): 5687-5692. doi:10.7150/jca.63159
Abstract Full text PDF PubMed PMC

Reviews

WFDC Protein: A Promising Diagnosis Biomarker of Ovarian Cancer
Chen Zhang, Haoyue Hu, Xiaoyan Wang, Yajuan Zhu, Ming Jiang
J. Cancer 2021; 12(18): 5404-5412. doi:10.7150/jca.57880
Abstract Full text PDF PubMed PMC

Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy
Run Huang, Huan Chen, Jiayu Liang, Yi Li, Jiali Yang, Chuang Luo, Youshan Tang, Yu Ding, Xing Liu, Qing Yuan, Hong Yu, Yingchun Ye, Wenfeng Xu, Xiang Xie
J. Cancer 2021; 12(18): 5543-5561. doi:10.7150/jca.54699
Abstract Full text PDF PubMed PMC

Advances in deubiquitinating enzymes in lung adenocarcinoma
Xi-Jia Zhou, Rui Li, Xiao Liu, Yi-Qing Qu
J. Cancer 2021; 12(18): 5573-5582. doi:10.7150/jca.56532
Abstract Full text PDF PubMed PMC

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