The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study

Chen, Qing; Chen, Xiaohui; Zhou, Lei; Chen, Fancheng; Hu, Annan; Wang, Ketao; Liang, Haifeng; Jiang, Libo; Li, Xilei; Dong, Jian

doi:10.7150/jca.60821



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2021; 12(18):5644-5653. doi:10.7150/jca.60821 This issue Cite

Research Paper

The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study

Qing Chen^1#, Xiaohui Chen^2#, Lei Zhou^1#, Fancheng Chen^1#, Annan Hu¹, Ketao Wang¹, Haifeng Liang¹, Libo Jiang^1✉, Xilei Li^1✉, Jian Dong^1✉

1. Department of Orthopeadic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
2. Department of Orthopaedic, First Affiliated Hospital of Xiamen University, Xiamen, 361003, Fujian, China.
#Qing Chen, Xiaohui Chen, Lei Zhou and Fancheng Chen contributed equally to this article.

✉ Corresponding authors: Libo Jiang, Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai, 200032, China. Email address: jiang.libosh.cn. Xilei Li, Department of Orthopaedic Surgery, Zhong More

Citation:

Chen Q, Chen X, Zhou L, Chen F, Hu A, Wang K, Liang H, Jiang L, Li X, Dong J. The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study. J Cancer 2021; 12(18):5644-5653. doi:10.7150/jca.60821. https://www.jcancer.org/v12p5644.htm

Other styles

Abstract

Objective: Lung cancer patients exhibit spinal metastases from a specific population, and with this study, we aimed to develop a model that can predict this particular group's survival.

Methods: Data were retrospectively collected from 83 lung cancer patients who underwent spinal metastasis surgery at our center from 2009 to 2021. After the initial assessment of treatment and scoring effects, a nomogram for survival prediction was created by identifying and integrating critical prognostic factors, followed by a consistency index (C-index) to measure consistency, and finally, a subject working characteristic curve (ROC) to compare the predictive accuracy of the three existing models.

Results: The mean postoperative survival was 14.7 months. Surgical treatment significantly improved the VAS and Frankel scores in lung cancer patients with spinal metastases. The revised Tokuhashi score underestimated the life expectancy of these patients. Six independent prognostic factors, including age, extraspinal bone metastasis foci, visceral metastasis, Frankel score, targeted therapy, and radiotherapy, were identified and incorporated into the model. Calibration curves for 3-, 6-, and 12-month overall survival showed a good concordance between predicted and actual risk. The nomogram C-index for the cohort study was 0.800 (95% confidence interval [CI]: 0.757-0.843). Model comparisons showed that the nomogram's prediction accuracy was better than revised Tokuhashi and Bauer's scoring systems.

Conclusions: Spine surgery offered patients the possibility of regaining neurological function. Having identified shortcomings in existing scoring systems, we have recreated and validated a new nomogram that can be used to predict survival outcomes in patients with spinal metastases from lung cancer, thereby assisting spinal surgeons in making surgical decisions and personalizing treatment for these patients.

Keywords: Lung Cancer, Spinal Metastasis, Nomogram

Citation styles

APA

Chen, Q., Chen, X., Zhou, L., Chen, F., Hu, A., Wang, K., Liang, H., Jiang, L., Li, X., Dong, J. (2021). The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study. Journal of Cancer, 12(18), 5644-5653. https://doi.org/10.7150/jca.60821.

ACS

Chen, Q.; Chen, X.; Zhou, L.; Chen, F.; Hu, A.; Wang, K.; Liang, H.; Jiang, L.; Li, X.; Dong, J. The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study. J. Cancer 2021, 12 (18), 5644-5653. DOI: 10.7150/jca.60821.

NLM

CSE

Chen Q, Chen X, Zhou L, Chen F, Hu A, Wang K, Liang H, Jiang L, Li X, Dong J. 2021. The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study. J Cancer. 12(18):5644-5653.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.