J Cancer 2021; 12(19):5888-5894. doi:10.7150/jca.60170 This issue Cite

Review

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis

Yuanyuan Zeng1,2*, Jie Zhang1*, Mengmeng Xu1*, Fuxian Chen1, Ruidong Zi1, Jicheng Yue1, Yanan Zhang1, Nannan Chen1✉, Y. Eugene Chin1✉

1. Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu, China.
2. Department of Respiratory Medicine, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
*These authors contributed equally to this work.

Citation:
Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer 2021; 12(19):5888-5894. doi:10.7150/jca.60170. https://www.jcancer.org/v12p5888.htm
Other styles

File import instruction

Abstract

Graphic abstract

In the last few years, cellular metabolic reprogramming has been acknowledged as a hallmark of human cancer and evaluated for its crucial role in supporting the proliferation and survival of human cancer cells. In a variety of human tumours, including hepatocellular carcinoma (HCC), breast cancer and non-small-cell lung cancer (NSCLC), a large amount of carbon is reused in serine/glycine biosynthesis, accompanied by higher expression of the key glycine synthetic enzyme mitochondrial serine hydroxymethyltransferase 2 (SHMT2). This enzyme can convert serine into glycine and a tetrahydrofolate-bound one-carbon unit, ultimately supporting thymidine synthesis and purine synthesis and promoting tumour growth. In tumour samples, elevated expression of SHMT2 was found to be associated with poor prognosis. In this review, the pivotal roles of SHMT2 in human carcinogenesis are described, highlighting the underlying regulatory mechanisms through promotion of tumour progression. In conclusion, SHMT2 may serve as a prognostic marker and a target for anticancer therapies.

Keywords: Serine hydroxymethyltransferase 2 (SHMT2), human carcinogenesis, predictive biomarker, cell proliferation, tumour growth


Citation styles

APA
Zeng, Y., Zhang, J., Xu, M., Chen, F., Zi, R., Yue, J., Zhang, Y., Chen, N., Chin, Y.E. (2021). Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. Journal of Cancer, 12(19), 5888-5894. https://doi.org/10.7150/jca.60170.

ACS
Zeng, Y.; Zhang, J.; Xu, M.; Chen, F.; Zi, R.; Yue, J.; Zhang, Y.; Chen, N.; Chin, Y.E. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J. Cancer 2021, 12 (19), 5888-5894. DOI: 10.7150/jca.60170.

NLM
Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer 2021; 12(19):5888-5894. doi:10.7150/jca.60170. https://www.jcancer.org/v12p5888.htm

CSE
Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. 2021. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer. 12(19):5888-5894.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.