Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis

Zeng, Yuanyuan; Zhang, Jie; Xu, Mengmeng; Chen, Fuxian; Zi, Ruidong; Yue, Jicheng; Zhang, Yanan; Chen, Nannan; Chin, Y. Eugene

doi:10.7150/jca.60170

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J Cancer 2021; 12(19):5888-5894. doi:10.7150/jca.60170 This issue Cite

Review

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis

Yuanyuan Zeng^1,2*, Jie Zhang^1*, Mengmeng Xu^1*, Fuxian Chen¹, Ruidong Zi¹, Jicheng Yue¹, Yanan Zhang¹, Nannan Chen^1✉, Y. Eugene Chin^1✉

1. Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu, China.
2. Department of Respiratory Medicine, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
*These authors contributed equally to this work.

Citation:

Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer 2021; 12(19):5888-5894. doi:10.7150/jca.60170. https://www.jcancer.org/v12p5888.htm

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Abstract

In the last few years, cellular metabolic reprogramming has been acknowledged as a hallmark of human cancer and evaluated for its crucial role in supporting the proliferation and survival of human cancer cells. In a variety of human tumours, including hepatocellular carcinoma (HCC), breast cancer and non-small-cell lung cancer (NSCLC), a large amount of carbon is reused in serine/glycine biosynthesis, accompanied by higher expression of the key glycine synthetic enzyme mitochondrial serine hydroxymethyltransferase 2 (SHMT2). This enzyme can convert serine into glycine and a tetrahydrofolate-bound one-carbon unit, ultimately supporting thymidine synthesis and purine synthesis and promoting tumour growth. In tumour samples, elevated expression of SHMT2 was found to be associated with poor prognosis. In this review, the pivotal roles of SHMT2 in human carcinogenesis are described, highlighting the underlying regulatory mechanisms through promotion of tumour progression. In conclusion, SHMT2 may serve as a prognostic marker and a target for anticancer therapies.

Keywords: Serine hydroxymethyltransferase 2 (SHMT2), human carcinogenesis, predictive biomarker, cell proliferation, tumour growth

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APA

Zeng, Y., Zhang, J., Xu, M., Chen, F., Zi, R., Yue, J., Zhang, Y., Chen, N., Chin, Y.E. (2021). Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. Journal of Cancer, 12(19), 5888-5894. https://doi.org/10.7150/jca.60170.

ACS

Zeng, Y.; Zhang, J.; Xu, M.; Chen, F.; Zi, R.; Yue, J.; Zhang, Y.; Chen, N.; Chin, Y.E. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J. Cancer 2021, 12 (19), 5888-5894. DOI: 10.7150/jca.60170.

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CSE

Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue J, Zhang Y, Chen N, Chin YE. 2021. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. J Cancer. 12(19):5888-5894.

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