Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases

Xiang, Hongjiao; Wu, Zecheng; Wang, Junmin; Wu, Tao

doi:10.7150/jca.57951

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2021; 12(19):5929-5937. doi:10.7150/jca.57951 This issue Cite

Review

Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases

Hongjiao Xiang, Zecheng Wu, Junmin Wang, Tao Wu^✉

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Citation:

Xiang H, Wu Z, Wang J, Wu T. Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases. J Cancer 2021; 12(19):5929-5937. doi:10.7150/jca.57951. https://www.jcancer.org/v12p5929.htm

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Abstract

The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain containing 481 amino acids. The I148M variant of PNPLA3 is a single nucleotide polymorphism, which is related to a variety of liver and cardiovascular diseases and their complications (such as non-alcoholic fatty liver disease, liver fibrosis, coronary artery disease). This review mainly describes the pathophysiological effects of PNPLA3 and its variants, and their roles in the progression of liver disease and its complications.

Keywords: PNPLA3, NAFLD, type 2 diabetes, liver fibrosis, hepatocellular carcinoma

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APA

Xiang, H., Wu, Z., Wang, J., Wu, T. (2021). Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases. Journal of Cancer, 12(19), 5929-5937. https://doi.org/10.7150/jca.57951.

ACS

Xiang, H.; Wu, Z.; Wang, J.; Wu, T. Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases. J. Cancer 2021, 12 (19), 5929-5937. DOI: 10.7150/jca.57951.

NLM

CSE

Xiang H, Wu Z, Wang J, Wu T. 2021. Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases. J Cancer. 12(19):5929-5937.

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