J Cancer 2021; 12(22):6695-6705. doi:10.7150/jca.62734 This issue

Research Paper

Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990-2019: Findings from Global Burden of Disease Study

Tongchao Zhang1,2, Hui Chen1,2, Yuan Zhang1,2, Xiaolin Yin1,2,3, Jinyu Man1,2,3, Xiaorong Yang1,2,4✉, Ming Lu1,2,3✉

1. Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China.
2. Clinical Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
3. Department of Epidemiology and Health Statistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
4. Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

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Citation:
Zhang T, Chen H, Zhang Y, Yin X, Man J, Yang X, Lu M. Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990-2019: Findings from Global Burden of Disease Study. J Cancer 2021; 12(22):6695-6705. doi:10.7150/jca.62734. Available from https://www.jcancer.org/v12p6695.htm

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Abstract

Graphic abstract

Background: The global disease burden of gastric cancer (GC) is still heavy. Understanding the patterns and trends of the global GC burden is important for developing precise prevention strategies.

Materials and Methods: The data of GC burden were retrieved from the Global Burden of Disease Study (2019). The estimated annual percentage change (EAPC) was calculated to estimate the temporal trends of the age-standardized incidence and mortality rates (ASIR and ASMR) of global GC by age-specific groups (15-49, 50-69, and ≥70 years), sexes, socio-demographic indexes (SDIs), regions, and countries.

Results: In 2019, the ASIR and ASMR of global GC increased with age in both sexes, and reached a peak in the older 70 age group. The ASIR and ASMR in males were higher than those in females. From 1990 to 2019, the global number of GC incident cases increased in both sexes in all age-specific groups; while the ASIR of GC decreased, and the most significant decrease was observed in the 50-69 age group [males: EAPC=-1.34, 95% CI: (-1.49, -1.18); females: EAPC= -2.09, 95% CI: (-2.22, -1.96)]. During the study period, downward trends in ASIR of GC were observed in both sexes in most SDI regions, GBD regions, and countries. Similar trends in ASMR of GC were also observed.

Conclusion: The global GC incidence and mortality rates decreased from 1990 to 2019 in both sexes, most GBD regions, and most countries. However, the GC burden was still heavy in some GBD regions and countries in special age-specific groups. It is important to formulate and implement tertiary prevention strategies based on the GC burden of age-specific groups in different regions and countries.

Keywords: Gastric cancer, Epidemiology, Global, Incidence, Mortality, Temporal trend