1. Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China. 2. Clinical Research Center for Wound Healing in Hunan Province, Changsha 410013, Hunan, China. * These authors contributed equally.
✉ Corresponding authors: Qianjin Liao or Deliang Cao, Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha 410013, Hunan, China. Tel:86-731-88651681; Fax:86-731-88651999; Email:march-oncom. Or 1814589590comMore
Citation:
Cao Z, Oyang L, Luo X, Xia L, Hu J, Lin J, Tan S, Tang Y, Zhou Y, Cao D, Liao Q. The roles of long non-coding RNAs in lung cancer. J Cancer 2022; 13(1):174-183. doi:10.7150/jca.65031. https://www.jcancer.org/v13p0174.htm
Lung cancer is the most common malignancy, being a serious threat of human lives. The incidence and mortality of lung cancer has been increasing rapidly in the past decades. Although the development of new therapeutic modes, such as target therapy, the overall survival rate of lung cancer remains low. It is urgent to advance the understanding of molecular oncology and find novel biomarkers and targets for the early diagnosis, treatment, and prognostic prediction of lung cancer. Long non-coding RNAs (lncRNAs) are non-protein coding RNA transcripts that are more than 200 nucleotides in length. LncRNAs exert diverse biological functions by regulating gene expressions at transcriptional, translational, and post-translational levels. In the past decade, it has been shown that lncRNAs are extensively involved in the pathogenesis of various diseases, including lung cancer. In this review, we highlighted the lncRNAs characterized in lung cancer and discussed their translational potential in lung cancer clinics.
Keywords: LncRNAs, lung cancer, tumor biomarkers, MALAT1, and HOTAIR
Citation styles
APA
Cao, Z., Oyang, L., Luo, X., Xia, L., Hu, J., Lin, J., Tan, S., Tang, Y., Zhou, Y., Cao, D., Liao, Q. (2022). The roles of long non-coding RNAs in lung cancer. Journal of Cancer, 13(1), 174-183. https://doi.org/10.7150/jca.65031.
ACS
Cao, Z.; Oyang, L.; Luo, X.; Xia, L.; Hu, J.; Lin, J.; Tan, S.; Tang, Y.; Zhou, Y.; Cao, D.; Liao, Q. The roles of long non-coding RNAs in lung cancer. J. Cancer 2022, 13 (1), 174-183. DOI: 10.7150/jca.65031.
NLM
Cao Z, Oyang L, Luo X, Xia L, Hu J, Lin J, Tan S, Tang Y, Zhou Y, Cao D, Liao Q. The roles of long non-coding RNAs in lung cancer. J Cancer 2022; 13(1):174-183. doi:10.7150/jca.65031. https://www.jcancer.org/v13p0174.htm
CSE
Cao Z, Oyang L, Luo X, Xia L, Hu J, Lin J, Tan S, Tang Y, Zhou Y, Cao D, Liao Q. 2022. The roles of long non-coding RNAs in lung cancer. J Cancer. 13(1):174-183.
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