J Cancer 2022; 13(1):268-277. doi:10.7150/jca.58982 This issue Cite

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The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer

Yong-Zhi Li1, Cheng Zhang1, Jun-Peng Pei1, Wan-Chuan Zhang1, Chun-Dong Zhang1,2, Dong-Qiu Dai1,3✉

1. Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
2. Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
3. Cancer Center, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.

Citation:
Li YZ, Zhang C, Pei JP, Zhang WC, Zhang CD, Dai DQ. The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer. J Cancer 2022; 13(1):268-277. doi:10.7150/jca.58982. https://www.jcancer.org/v13p0268.htm
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Abstract

Graphic abstract

Tumors are neogrowths formed by the growth of normal cells or tissues through complex mechanisms under the influence of many factors. The occurrence and development of tumors are affected by many factors. Pescadillo ribosomal biogenesis factor 1 (PES1) has been identified as a cancer-related gene. The study of these genes may open up new avenues for early diagnosis, treatment and prognosis of tumors. As a nucleolar protein and part of the Pes1/Bop1/WDR12 (PeBoW) complex, PES1 is involved in ribosome biogenesis and DNA replication. Many studies have shown that high expression of PES1 is often closely related to the occurrence, proliferation, invasion, metastasis, prognosis and sensitivity to chemotherapeutics of various human malignant tumors through a series of molecular mechanisms and signaling pathways. The molecules that regulate the expression of PES1 include microRNA (miRNA), circular RNA (circRNA), c-Jun, bromodomain-containing protein 4 (BRD4) and nucleolar phosphoprotein B23. However, the detailed pathogenic mechanisms of PES1 overexpression in human malignancies remains unclear. This article summarizes the role of PES1 in the carcinogenesis, prognosis and treatment of multiple tumors, and introduces the molecular mechanisms and signal transduction pathways related to PES1.

Keywords: PES1, cancer, signaling pathway, treatment, proliferation


Citation styles

APA
Li, Y.Z., Zhang, C., Pei, J.P., Zhang, W.C., Zhang, C.D., Dai, D.Q. (2022). The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer. Journal of Cancer, 13(1), 268-277. https://doi.org/10.7150/jca.58982.

ACS
Li, Y.Z.; Zhang, C.; Pei, J.P.; Zhang, W.C.; Zhang, C.D.; Dai, D.Q. The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer. J. Cancer 2022, 13 (1), 268-277. DOI: 10.7150/jca.58982.

NLM
Li YZ, Zhang C, Pei JP, Zhang WC, Zhang CD, Dai DQ. The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer. J Cancer 2022; 13(1):268-277. doi:10.7150/jca.58982. https://www.jcancer.org/v13p0268.htm

CSE
Li YZ, Zhang C, Pei JP, Zhang WC, Zhang CD, Dai DQ. 2022. The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer. J Cancer. 13(1):268-277.

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