J Cancer 2022; 13(3):823-830. doi:10.7150/jca.65129 This issue Cite

Research Paper

Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer

Wei Yang1,2#, Yating Yao3#, Yingying Chen4, Fangsi Jin3, Tingting Zheng3, Xinyi Ai3, Ting Zhang3, Chunming Ding1,2✉, Minghua Jiang3✉

1. School of Laboratory Medicine and Life Science, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, China.
2. Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou Medical University, 325035 Wenzhou, Zhejiang, China.
3. Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
4. Otolaryngology department, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
#Contributed equally.

Citation:
Yang W, Yao Y, Chen Y, Jin F, Zheng T, Ai X, Zhang T, Ding C, Jiang M. Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. J Cancer 2022; 13(3):823-830. doi:10.7150/jca.65129. https://www.jcancer.org/v13p0823.htm
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Abstract

Graphic abstract

Purpose: To determine the prognostic significance of postoperative platelet/preoperative platelet ratio (PPR) in patients with operable non-small cell lung cancer (NSCLC), and assess its prognostic benefit compared to models relying solely preoperative platelet counts (PLT).

Materials and Methods: A retrospective analysis of 403 patients who underwent radical resection of NSCLC in our institution from 2013 to 2018 was conducted to assess the prognostic significance of PLT and PPR. Progression-free survival (PFS) and overall survival (OS) were performed by the Kaplan-Meier method. Single-factor and multi-factor COX regression models were used to determine factors that affect long-term outcomes. Time-dependent ROC was used to evaluate the value of PPR in predicting the prognosis.

Results: A significant association between high PLT and PPR and poor long-term patient survival outcomes was observed. The median PFS and OS of NSCLC patients with high PLT were 25 months and 29 months, which was significantly shorter than that of patients with low PLT (30 months and 33 months) (both P = 0.002). In addition, the median PFS and OS of NSCLC patients with high PPR were 18 months and 26.5 months, which was significantly shorter than that of patients with low PPR (33 months and 35 months) (both P<0.001). Univariate and Multivariate analysis using Cox regression model showed that PLT and PPR were independent factors affecting PFS and OS. Time-dependent ROC showed that the predictive capability of PLT and PPR preserved well when they were compared over time following surgery. The AUCs of PLT and PPR to predict 1-year PFS and OS, 3-year PFS and OS, 5-year PFS and OS stabilized between 0.528-0.607. PPR showed significantly higher accuracy than PLT in the prediction of 1-year and 3-year PFS and OS.

Conclusions: Elevated PPR is significantly related to the adverse outcomes of patients with NSCLC. PPR can stably predict the long-term prognosis of patients, and can be used as a reliable indicator for evaluating the prognosis of patients with operable NSCLC.

Keywords: Non-small cell lung cancer (NSCLC), postoperative platelet/preoperative platelet ratio (PPR), prognosis, time-dependent ROC


Citation styles

APA
Yang, W., Yao, Y., Chen, Y., Jin, F., Zheng, T., Ai, X., Zhang, T., Ding, C., Jiang, M. (2022). Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. Journal of Cancer, 13(3), 823-830. https://doi.org/10.7150/jca.65129.

ACS
Yang, W.; Yao, Y.; Chen, Y.; Jin, F.; Zheng, T.; Ai, X.; Zhang, T.; Ding, C.; Jiang, M. Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. J. Cancer 2022, 13 (3), 823-830. DOI: 10.7150/jca.65129.

NLM
Yang W, Yao Y, Chen Y, Jin F, Zheng T, Ai X, Zhang T, Ding C, Jiang M. Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. J Cancer 2022; 13(3):823-830. doi:10.7150/jca.65129. https://www.jcancer.org/v13p0823.htm

CSE
Yang W, Yao Y, Chen Y, Jin F, Zheng T, Ai X, Zhang T, Ding C, Jiang M. 2022. Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. J Cancer. 13(3):823-830.

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