J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967 This issue Cite

Research Paper

Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma

Dehua Hu1#, Yufeng Cai1#, Lan He2, Hao Jiang1✉

1. Department of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
2. College of Biology, Hunan University, Changsha, Hunan 410078, China.
#Dehua Hu and Yufeng Cai contributed equally to this article and share first authorship.

Citation:
Hu D, Cai Y, He L, Jiang H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967. https://www.jcancer.org/v14p0250.htm
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Abstract

Graphic abstract

Oral squamous cell carcinoma (OSCC) is a highly invasive type of head and neck cancer. Circular RNA (circRNA) acts as a competing endogenous RNA (ceRNA) and involves in pathogenesis of many diseases. However, the circRNA-miRNA-mRNA network and relationship between ceRNA and immune infiltration in OSCC remain unknown. In this study, we established a ceRNA network, including 89 circRNAs, 43 miRNAs and 223 mRNAs, and found that 233 genes are mainly related to malignant signalling pathways (including "Integrin family cell surface interactions" and "Epithelial-to-mesenchymal transition" pathways) and five potential biomarkers (SLC20A1, PITX2, hsa-mir-135b, hsa-mir-377 and hsa-let-7c). Meanwhile, we established a prognostic model based on clinical risk, and revealed the relationship between immune infiltrating cells and biomarkers in OSCC. Taken together, our study is helpful to reveal the pathogenesis of oral squamous cell carcinoma.

Keywords: Oral squamous cell carcinoma, circRNA, ceRNA, immune infiltration, bioinformatics


Citation styles

APA
Hu, D., Cai, Y., He, L., Jiang, H. (2023). Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. Journal of Cancer, 14(2), 250-261. https://doi.org/10.7150/jca.79967.

ACS
Hu, D.; Cai, Y.; He, L.; Jiang, H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J. Cancer 2023, 14 (2), 250-261. DOI: 10.7150/jca.79967.

NLM
Hu D, Cai Y, He L, Jiang H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967. https://www.jcancer.org/v14p0250.htm

CSE
Hu D, Cai Y, He L, Jiang H. 2023. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer. 14(2):250-261.

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