Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma

Hu, Dehua; Cai, Yufeng; He, Lan; Jiang, Hao

doi:10.7150/jca.79967



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967 This issue Cite

Research Paper

Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma

Dehua Hu^1#, Yufeng Cai^1#, Lan He², Hao Jiang^1✉

1. Department of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
2. College of Biology, Hunan University, Changsha, Hunan 410078, China.
^#Dehua Hu and Yufeng Cai contributed equally to this article and share first authorship.

Citation:

Hu D, Cai Y, He L, Jiang H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer 2023; 14(2):250-261. doi:10.7150/jca.79967. https://www.jcancer.org/v14p0250.htm

Other styles

Abstract

Oral squamous cell carcinoma (OSCC) is a highly invasive type of head and neck cancer. Circular RNA (circRNA) acts as a competing endogenous RNA (ceRNA) and involves in pathogenesis of many diseases. However, the circRNA-miRNA-mRNA network and relationship between ceRNA and immune infiltration in OSCC remain unknown. In this study, we established a ceRNA network, including 89 circRNAs, 43 miRNAs and 223 mRNAs, and found that 233 genes are mainly related to malignant signalling pathways (including "Integrin family cell surface interactions" and "Epithelial-to-mesenchymal transition" pathways) and five potential biomarkers (SLC20A1, PITX2, hsa-mir-135b, hsa-mir-377 and hsa-let-7c). Meanwhile, we established a prognostic model based on clinical risk, and revealed the relationship between immune infiltrating cells and biomarkers in OSCC. Taken together, our study is helpful to reveal the pathogenesis of oral squamous cell carcinoma.

Keywords: Oral squamous cell carcinoma, circRNA, ceRNA, immune infiltration, bioinformatics

Citation styles

APA

Hu, D., Cai, Y., He, L., Jiang, H. (2023). Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. Journal of Cancer, 14(2), 250-261. https://doi.org/10.7150/jca.79967.

ACS

Hu, D.; Cai, Y.; He, L.; Jiang, H. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J. Cancer 2023, 14 (2), 250-261. DOI: 10.7150/jca.79967.

NLM

CSE

Hu D, Cai Y, He L, Jiang H. 2023. Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma. J Cancer. 14(2):250-261.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.