J Cancer 2023; 14(6):927-934. doi:10.7150/jca.83189 This issue Cite

Research Paper

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study

Juan Xiong1#, Rong Liu1#, Yuying Zhang1, Wenting Song2✉

1. Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang City 330029, Jiangxi, China.
2. Department of Medical Oncology, Nanchang People's Hospital, The Third Hospital of Nanchang City, Nanchang City 330002, Jiangxi, China.
# These authors contributed equally to this work and share first authorship.

Citation:
Xiong J, Liu R, Zhang Y, Song W. Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study. J Cancer 2023; 14(6):927-934. doi:10.7150/jca.83189. https://www.jcancer.org/v14p0927.htm
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Abstract

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Purpose: This study aimed to evaluate and analyze the efficacy and safety of low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy.

Methods: Patients with nasopharyngeal carcinoma from Jiangxi cancer hospital were randomly divided into two cohorts. The training cohort (n= 50) received low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy, and the control cohort (n= 50) received 0.02% nitrofurazone lavage fluid. The primary endpoint of the study was result of short-term efficacy. Second endpoints were assessment of the linear visual analogue scale score and the incidences rate of nasopharyngeal radiation related toxicity.

Results: All patients had completed the scheduled nasopharyngeal radiotherapy except two patients in control cohort. The complete response, partial response, stable disease and disease objective response of nasopharyngeal primary tumor observed in the training cohort included 18 cases, 23 cases, 9 cases and 41 cases respectively, while in the control cohort 20 cases, 25 cases, 5 cases and 45 cases were recorded, respectively. The study showed a significant discrepancy in the incidence rate of radiation-related mucosa damage between the two. Specifically, Grade 1 and 2 included 37 cases (74.0%) in the training cohort, while in the control cohort the cases were 20 (40.0%). Grade 3 and 4 damage however reported an incidence of 26.0% and 60%, respectively, which clearly constitutes a significant statistical difference (P = 0.002). The assessment of linear visual analogue scale showed that the patients self-conscious comfortable feeling in the training cohort were significantly higher than in the control cohort (P = 0.003).

Conclusions: low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma patients is effective and safe, and can reduce nasopharyngeal local mucosa radiation related toxicity after radiotherapy.

Keywords: Nasopharyngeal Carcinoma, Nasopharyngeal Lavage, Hydrogen Peroxide, Nitrofurazone, Radiotherapy, Adverse Events


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APA
Xiong, J., Liu, R., Zhang, Y., Song, W. (2023). Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study. Journal of Cancer, 14(6), 927-934. https://doi.org/10.7150/jca.83189.

ACS
Xiong, J.; Liu, R.; Zhang, Y.; Song, W. Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study. J. Cancer 2023, 14 (6), 927-934. DOI: 10.7150/jca.83189.

NLM
Xiong J, Liu R, Zhang Y, Song W. Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study. J Cancer 2023; 14(6):927-934. doi:10.7150/jca.83189. https://www.jcancer.org/v14p0927.htm

CSE
Xiong J, Liu R, Zhang Y, Song W. 2023. Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study. J Cancer. 14(6):927-934.

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