ISSN: 1837-9664Journal of Cancer
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J Cancer 2023; 14(8):1427-1442. doi:10.7150/jca.83097 This issue Cite
Research Paper
Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer
1. The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
2. Qilu Hospital of Shandong University, Jinan, Shandong, China.
3. Department of Pulmonary and Critical Care Medicine, Laboratory of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, China.
# These authors contributed equally.
Citation:
Wang RA, Zhang MY, Jiang YX, Wang XD, Qu JJ, Yue YL, Qu YQ. Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer. J Cancer 2023; 14(8):1427-1442. doi:10.7150/jca.83097. https://www.jcancer.org/v14p1427.htm
Other stylesAbstract
Autophagy plays an important role in non-small cell lung cancer (NSCLC). We aimed to establish novel autophagy-related tumor subtypes to distinguish the prognosis of NSCLC. In this study, gene expression profiles, mutation data and clinical information obtained from the Cancer Genome Atlas. Kaplan Meier-plotter could evaluate prognostic value of autophagy-related genes. Consensus clustering revealed autophagy-related tumor subtypes. Gene expression profiles, mutation data and immune infiltration signatures were identified, oncogenic pathways and gene-drug interactions were performed according to the clusters. Finally, a total of 23 prognostic genes were screened and consensus clustering analysis divided the NSCLC into 2 clusters. The mutation signature showed that 6 genes are special. Immune infiltration signatures showed that higher fraction of immune cells was associated with cluster 1. The oncogenic pathways and gene-drug interactions also showed different patterns. In conclusion, autophagy-related tumor subtypes have different prognosis. Understanding the subtypes of NSCLC are helpful to accurately identify the NSCLC and personalized treatment.
Keywords: non-small cell lung cancer, autophagy, prognostic subtype, mutation, immune cell infiltration
Citation styles
APA
Wang, R.A., Zhang, M.Y., Jiang, Y.X., Wang, X.D., Qu, J.J., Yue, Y.L., Qu, Y.Q. (2023). Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer. Journal of Cancer, 14(8), 1427-1442. https://doi.org/10.7150/jca.83097.
ACS
Wang, R.A.; Zhang, M.Y.; Jiang, Y.X.; Wang, X.D.; Qu, J.J.; Yue, Y.L.; Qu, Y.Q. Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer. J. Cancer 2023, 14 (8), 1427-1442. DOI: 10.7150/jca.83097.
NLM
Wang RA, Zhang MY, Jiang YX, Wang XD, Qu JJ, Yue YL, Qu YQ. Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer. J Cancer 2023; 14(8):1427-1442. doi:10.7150/jca.83097. https://www.jcancer.org/v14p1427.htm
CSE
Wang RA, Zhang MY, Jiang YX, Wang XD, Qu JJ, Yue YL, Qu YQ. 2023. Autophagy-related tumor subtypes associated with significant gene expression profiles and immune cell infiltration signatures to reveal the prognosis of non-small cell lung cancer. J Cancer. 14(8):1427-1442.
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