Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

J Cancer 2023; 14(9):1479-1485. doi:10.7150/jca.83395 This issue Cite

Research Paper

Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis

Maïwenn Kerdreux1, Sofia Edin1, Thyra Löwenmark1, Vicky Bronnec1, Anna Löfgren-Burström1, Carl Zingmark1, Ingrid Ljuslinder2, Richard Palmqvist1†, Agnes Ling1†✉

1. Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
2. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
†Shared last authorship

✉ Corresponding author: Agnes Ling, Department of Medical Biosciences, Pathology, Building 6M, Umeå University, SE-90185 Umeå, Sweden. Phone: +46(0)907854487; e-mail: agnes.lingse.

Citation:
Kerdreux M, Edin S, Löwenmark T, Bronnec V, Löfgren-Burström A, Zingmark C, Ljuslinder I, Palmqvist R, Ling A. Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. J Cancer 2023; 14(9):1479-1485. doi:10.7150/jca.83395. https://www.jcancer.org/v14p1479.htm
Other styles

File import instruction

Abstract

Graphic abstract

Microbiota dysbiosis may affect both the development and progression of colorectal cancer (CRC). Large metagenomic studies have highlighted specific oral bacteria linked to CRC including Porphyromonas gingivalis. Few studies have however analysed the implications of this bacterium in CRC progression and survival. In this study, we investigated the intestinal presence of P. gingivalis by qPCR in both faecal and mucosal samples from two different patient cohorts, including patients with precancerous dysplasia or CRC, as well as controls. P. gingivalis was detected in 2.6-5.3% of CRC patients and significantly different levels of P. gingivalis were found in faeces of CRC patients compared to controls (P = 0.028). Furthermore, an association was found between the presence of P. gingivalis in faeces and tumour tissue (P < 0.001). Our findings further suggested a potential link between mucosal P. gingivalis and tumours of MSI subtype (P = 0.040). Last but not least, patients with faecal P. gingivalis were found to have a significantly decreased cancer-specific survival (P = 0.040). In conclusion, P. gingivalis could be linked to patients with CRC and to a worse patient prognosis. Further studies are needed to elucidate the role of P. gingivalis in CRC pathogenesis.

Keywords: Porphyromonas gingivalis, colorectal cancer, microbiota, survival

Citation styles

APA
Kerdreux, M., Edin, S., Löwenmark, T., Bronnec, V., Löfgren-Burström, A., Zingmark, C., Ljuslinder, I., Palmqvist, R., Ling, A. (2023). Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. Journal of Cancer, 14(9), 1479-1485. https://doi.org/10.7150/jca.83395.

ACS
Kerdreux, M.; Edin, S.; Löwenmark, T.; Bronnec, V.; Löfgren-Burström, A.; Zingmark, C.; Ljuslinder, I.; Palmqvist, R.; Ling, A. Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. J. Cancer 2023, 14 (9), 1479-1485. DOI: 10.7150/jca.83395.

NLM
Kerdreux M, Edin S, Löwenmark T, Bronnec V, Löfgren-Burström A, Zingmark C, Ljuslinder I, Palmqvist R, Ling A. Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. J Cancer 2023; 14(9):1479-1485. doi:10.7150/jca.83395. https://www.jcancer.org/v14p1479.htm

CSE
Kerdreux M, Edin S, Löwenmark T, Bronnec V, Löfgren-Burström A, Zingmark C, Ljuslinder I, Palmqvist R, Ling A. 2023. Porphyromonas gingivalis in Colorectal Cancer and its Association to Patient Prognosis. J Cancer. 14(9):1479-1485.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use