1. Department of Biochemistry, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
2. Department of Obstetrics Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
3. Department of Physics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta, Indonesia.
4. Master Student of Pharmacology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Erythrocyte sedimentation rate order (ESRO), platelet-lymphocyte ratio (PLR), red cell distribution width (RDW), and neutrophil-lymphocyte ratio (NLR) are hematological parameters that reflect the presence of biomarkers in epithelial ovarian cancer (EOC). This study evaluated the best haematological parameter in order to distinguish between EOC patients and healthy individuals. There were a total of 33 patients with EOC as subjects treated in Dr. Sardjito hospital, Yogyakarta, Indonesia and 32 volunteer subjects as controls. Curves of receiver operation, area under the curve, specificity, and sensitivity were estimated. To demonstrate EOC's presence, the ESRO was better than the hematological parameters of RDW, PLR, and NLR (AUC = 0.9245, 0.9010, 0.8351, and 0.7457, respectively; sensitivity and specificity = 83.3 and 90.6; 88.9 and 87.5; 100.0 and 68.8; and 94.4 and 53.1, respectively) at the cut-off points 1,125, 44.2, 163.2, and 2,551. Hence, ESRO is a better parameter to indicate the presence of EOC compared to RDW, PLR and NLR.
Keywords: biomarkers, EOC, ESRO, NLR, RDW