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J Cancer 2024; 15(2):309-316. doi:10.7150/jca.89059 This issue Cite

Research Paper

Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property

Yun Haeng Lee1, Myeong Uk Kuk1, Moon Kyoung So1, Hyon Jin Park1, Eun Seon Song1, Jiho Park1, Jee hee Yoon1, Hyung Wook Kwon1,2,✉, Jaehyuk Choi1,✉, Joon Tae Park1,2,✉

1. Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
2. Convergence Research Center for Insect Vectors, Incheon National University, Incheon 22012, Korea.

✉ Corresponding authors: Hyung Wook Kwon, Ph.D., Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Korea. Tel: +82-32-835-8090; E-mail address: hwkwonac.kr. Jaehyuk Choi, Ph.D., Di More

Citation:
Lee YH, Kuk MU, So MK, Park HJ, Song ES, Park J, Yoon Jh, Kwon HW, Choi J, Park JT. Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. J Cancer 2024; 15(2):309-316. doi:10.7150/jca.89059. https://www.jcancer.org/v15p0309.htm
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Abstract

Graphic abstract

Cancer cells are characterized by apoptosis evasion and uncontrolled cell cycle progression. To combat these characteristics, efforts have been made to find novel natural-source anticancer compounds. The aim of this work is to find new anticancer compounds in Polyporus ulleungus (P. ulleungus) mycelial culture extracts. P. ulleungus mycelium was cultured on four individual media (DYB, MEB, MYB, and PDB) and four extracts were generated from the mycelium culture media. Extracts of P. ulleungus mycelium cultured in MEB medium (pu-MEB) significantly reduced cancer cell growth by triggering apoptosis and S phase arrest. Furthermore, the anticancer effects of pu-MEB were not confined to one type of cancer. Taken together, our results confirmed that P. ulleungus mycelia cultured in MEB medium produce metabolites that exhibit anticancer properties. Development of an optimal medium for P. ulleungus mycelium through optimization of medium components will enable P. ulleungus mycelium to produce metabolites with more anticancer efficacy.

Keywords: Polyporus ulleungus, mycelium culture extract, drug screening

Citation styles

APA
Lee, Y.H., Kuk, M.U., So, M.K., Park, H.J., Song, E.S., Park, J., Yoon, J.h., Kwon, H.W., Choi, J., Park, J.T. (2024). Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. Journal of Cancer, 15(2), 309-316. https://doi.org/10.7150/jca.89059.

ACS
Lee, Y.H.; Kuk, M.U.; So, M.K.; Park, H.J.; Song, E.S.; Park, J.; Yoon, J.h.; Kwon, H.W.; Choi, J.; Park, J.T. Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. J. Cancer 2024, 15 (2), 309-316. DOI: 10.7150/jca.89059.

NLM
Lee YH, Kuk MU, So MK, Park HJ, Song ES, Park J, Yoon Jh, Kwon HW, Choi J, Park JT. Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. J Cancer 2024; 15(2):309-316. doi:10.7150/jca.89059. https://www.jcancer.org/v15p0309.htm

CSE
Lee YH, Kuk MU, So MK, Park HJ, Song ES, Park J, Yoon Jh, Kwon HW, Choi J, Park JT. 2024. Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property. J Cancer. 15(2):309-316.

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