A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of <i>CD27</i>

Wang, Yongfeng; Guan, Ling; Zhao, Yanzong; Yang, Yanling; Wang, Yitong; Feng, Shengjiao; Zou, Anqi; Li, Yawei; Zhou, Botao; Zhang, Dongzhi; Che, Weiqi; Liu, Fangyu

doi:10.7150/jca.85446

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J Cancer 2024; 15(2):508-525. doi:10.7150/jca.85446 This issue Cite

Research Paper

A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of CD27

Yongfeng Wang^1,2,3,4, Ling Guan⁵, Yanzong Zhao⁵, Yanling Yang⁶, Yitong Wang⁵, Shengjiao Feng⁵, Anqi Zou⁵, Yawei Li^2,3,4, Botao Zhou^2,3,4, Dongzhi Zhang⁴, Weiqi Che^1✉, Fangyu Liu^1✉

1. The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, 730000, China.
2. General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, Gansu, 730000, China.
3. Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Gansu 730000, China.
4. NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, 730000, China.
5. School of Stomatology, Lanzhou University, Lanzhou, Gansu, 730000, China.
6. College of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Citation:

Wang Y, Guan L, Zhao Y, Yang Y, Wang Y, Feng S, Zou A, Li Y, Zhou B, Zhang D, Che W, Liu F. A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of CD27. J Cancer 2024; 15(2):508-525. doi:10.7150/jca.85446. https://www.jcancer.org/v15p0508.htm

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Abstract

Background: CD27 is an immunological checkpoint gene, plays a critical function inInhibition or activation of cancer immunity. The CD27/CD27L axis is its pathway of action. Therefore, our goal was to examine the predictive role of CD27 in the clinical prognosis of 33 cancer types and its functions in cancer progression, as well as explore the link between pan-cancer CD27 gene expression and immune infiltration.

Methods: By comprehensive use of datasets and methods from TCGA, cBioPortal, GTEx, HPA, KM-plotter, Spearman, CellMinerTM, R packages and RT-qPCR, we delved deeper into the potential impact of the CD27 on cancer development. These include expression differences, immune infiltration, matrix infiltration, gene mutations, DNA methylation, signaling pathways, TMB, MSI, and prognosis. Also, we explored CD27 interactions with different drugs.

Results: The results showed that, mutated CD27 was highly expressed in most cancers. The CD27 showed strong diagnostic value in 4 cancers and marked a positive prognosis for CESC, intracervical adenocarcinoma, HNSC, and endometrial cancer, and a poor prognosis for UVM. In addition, CD27 affects multiple immune and inflammatory signaling pathways and is positively correlated with immune cell infiltration, T cell differentiation, macrophage M1 polarization, stromal infiltration, and drug sensitivity. DNA methylation is involved in CD27 expression in cancer.

Conclusion: CD27, which is mutated in cancers and appears widely highly expressed and altered tumor immune invasion and stromal invasion by affecting multiple immune-related and inflammation signaling pathways, plays a significant role in CESC, HNSC, UCEC and UVM, and may be used as a therapeutic target for related cancers.

Keywords: CD27, pan-cancer, immune, prognosis.

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APA

Wang, Y., Guan, L., Zhao, Y., Yang, Y., Wang, Y., Feng, S., Zou, A., Li, Y., Zhou, B., Zhang, D., Che, W., Liu, F. (2024). A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of CD27. Journal of Cancer, 15(2), 508-525. https://doi.org/10.7150/jca.85446.

ACS

Wang, Y.; Guan, L.; Zhao, Y.; Yang, Y.; Wang, Y.; Feng, S.; Zou, A.; Li, Y.; Zhou, B.; Zhang, D.; Che, W.; Liu, F. A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of CD27. J. Cancer 2024, 15 (2), 508-525. DOI: 10.7150/jca.85446.

NLM

CSE

Wang Y, Guan L, Zhao Y, Yang Y, Wang Y, Feng S, Zou A, Li Y, Zhou B, Zhang D, Che W, Liu F. 2024. A Comprehensive Pan-cancer Analysis of the Biological Immunomodulatory Function and Clinical Value of CD27. J Cancer. 15(2):508-525.

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