Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma

Gao, Luying; Liu, Ruifeng; Xia, Yu; Pan, Aonan; Shi, Xinlong; Ma, Liyuan; Ji, Jiang; Hu, Ya; Li, Xiaoyi; An, Yuang; Luo, Nengwen; Liang, Zhiyong; Zhou, Liangrui; Jiang, Yuxin

doi:10.7150/jca.92656

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J Cancer 2024; 15(8):2206-2213. doi:10.7150/jca.92656 This issue Cite

Research Paper

Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma

Luying Gao^1#, Ruifeng Liu^1#, Yu Xia^1✉, Aonan Pan¹, Xinlong Shi¹, Liyuan Ma¹, Jiang Ji¹, Ya Hu², Xiaoyi Li², Yuang An¹, Nengwen Luo¹, Zhiyong Liang³, Liangrui Zhou³, Yuxin Jiang^1✉

1. Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
2. Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
3. Department of Pathology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
^#These authors contributed equally to this work.

Citation:

Gao L, Liu R, Xia Y, Pan A, Shi X, Ma L, Ji J, Hu Y, Li X, An Y, Luo N, Liang Z, Zhou L, Jiang Y. Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma. J Cancer 2024; 15(8):2206-2213. doi:10.7150/jca.92656. https://www.jcancer.org/v15p2206.htm

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Abstract

Objective: To explore the potential value of a novel marker, KIF-12, in the progression and prognosis of papillary thyroid carcinoma (PTC) through integrative bioinformatics analysis, and clinical sample validation of the prognostic value of KIF-12.

Materials and Methods: We extracted the clinicopathological data of 502 PTC patients from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset to identify reliable differentially expressed genes (DEGs) between high and low KIF12 expression groups. Functional enrichment analysis was performed on upregulated DEGs. Gene set enrichment analysis (GESA) was performed to identify the biological pathways. We further applied Cox analysis to determine independent risk factors associated with the PTC progression-free interval (PFI), and a nomogram was established to predict disease outcome. Finally, the prognostic value of KIF12 was validated by means of clinical samples from PTC patients with and without lateral lymph node metastasis.

Results: On the basis of the TCGA-THCA database, we found that low KIF-12 expression was significantly related to a higher TNM stage (p<0.05), BRAF mutation status (p = 0.019), and extrathyroidal extension (p<0.001). KIF-12 was an independent prognostic factor of PTC (OR=0.319, 95% CI=0.130-0.784, P=0.013). The prognostic value of KIF12 was also successfully validated in clinical samples from twenty-nine PTC patients with lateral lymph node metastasis by comparison with twenty-two PTC patients without lymph node metastasis (P = 0.004).

Conclusions: We report that KIF-12 has a tumor suppressive function in PTC and may be a useful prognostic tool to predict patient outcomes.

Keywords: KIF-12, Prognosis, Differentiated thyroid carcinoma, Thyroid

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APA

Gao, L., Liu, R., Xia, Y., Pan, A., Shi, X., Ma, L., Ji, J., Hu, Y., Li, X., An, Y., Luo, N., Liang, Z., Zhou, L., Jiang, Y. (2024). Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma. Journal of Cancer, 15(8), 2206-2213. https://doi.org/10.7150/jca.92656.

ACS

Gao, L.; Liu, R.; Xia, Y.; Pan, A.; Shi, X.; Ma, L.; Ji, J.; Hu, Y.; Li, X.; An, Y.; Luo, N.; Liang, Z.; Zhou, L.; Jiang, Y. Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma. J. Cancer 2024, 15 (8), 2206-2213. DOI: 10.7150/jca.92656.

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CSE

Gao L, Liu R, Xia Y, Pan A, Shi X, Ma L, Ji J, Hu Y, Li X, An Y, Luo N, Liang Z, Zhou L, Jiang Y. 2024. Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma. J Cancer. 15(8):2206-2213.

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