J Cancer 2015; 6(6):502-510. doi:10.7150/jca.11403 This issue Cite

Research Paper

Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma

Xue-Xia Liang1, 3†, Qun Li1, 2 †, Zhen Su1, 2†, Xiao-Wen Lan1, 2, Pu-Yun Ouyang1, 2, Yan-Ping Mao1, 2, Ding-Bo Shi1, Wu-Guo Deng1, Zhi-Bin Cheng3, Si-Yang Wang3, Fang-Yun Xie1, 2 ✉

1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China.
2. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China.
3. Department of Radiation Oncology, the Fifth Affiliated Hospital of Sun Yat-sen University, 52 Meihua East Road, Zhuhai 519000, China.
† These authors contributed equally to this article.

Citation:
Liang XX, Li Q, Su Z, Lan XW, Ouyang PY, Mao YP, Shi DB, Deng WG, Cheng ZB, Wang SY, Xie FY. Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma. J Cancer 2015; 6(6):502-510. doi:10.7150/jca.11403. https://www.jcancer.org/v06p0502.htm
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Abstract

Purpose: To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC).

Materials and Methods: Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant chemoradiotherapy (CCRT group), were enrolled in this study, who were regrouped according to pre-radiotherapy Hb (pre-RT Hb), post-radiotherapy Hb (post-RT Hb) and individual Hb decrease through radiotherapy or CCRT (△Hb), respectively. Survival curves were estimated using Kaplan-Meier method and compared by log-rank test. Multivariate analysis was performed using the COX proportional hazard model and binary logistic regression model.

Results: A poorer 5-year disease-free survival (DFS) was observed when pre-RT Hb<130.00 g/L. However, post-RT Hb<130.00 g/L was associated with significantly poorer 5-year locoregional recurrence-free survival (LRFS) (P=0.010) and disease specific survival (DSS) (P=0.008). Multivariate analysis with the COX proportional hazard model identified post-RT Hb<130.00 g/L as an independent negative prognostic factor for both LRFS (hazard ratio [HR], 1.896; 95% confidence interval [CI], 1.158-3.106; P=0.011) and DSS (HR, 1.767; 95% CI, 1.152-2.711; P=0.009). Similarly, △Hb <-15.00 g/L also predicted poorer 5-year LRFS (P=0.024) and DSS (P=0.015), which was confirmed in multivariate analysis as an independent adverse prognostic factor for LRFS (HR, 1.586; 95% CI, 1.058-2.377; P=0.026) and DSS (HR, 1.556; 95% CI, 1.087-2.227; P=0.016), respectively. Multivariate analysis with binary logistic regression model indicated that CCRT was a significantly independent predictor for post-RT Hb <130.00 g/L and △Hb < -15.00 g/L.

Conclusions: Chemoradiotherapy-induced decreased Hb levels have negative influence on locoregional control and survival, and might counteract the benefit of neoadjuvant/concomitant chemotherapy. Further studies on supportive care to maintain sufficient Hb level during chemo-radiotherapy are warranted.

Keywords: concomitant chemotherapy, hemoglobin decrease, nasopharyngeal carcinoma, neoadjuvant chemotherapy, prognostication, radiotherapy.


Citation styles

APA
Liang, X.X., Li, Q., Su, Z., Lan, X.W., Ouyang, P.Y., Mao, Y.P., Shi, D.B., Deng, W.G., Cheng, Z.B., Wang, S.Y., Xie, F.Y. (2015). Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma. Journal of Cancer, 6(6), 502-510. https://doi.org/10.7150/jca.11403.

ACS
Liang, X.X.; Li, Q.; Su, Z.; Lan, X.W.; Ouyang, P.Y.; Mao, Y.P.; Shi, D.B.; Deng, W.G.; Cheng, Z.B.; Wang, S.Y.; Xie, F.Y. Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma. J. Cancer 2015, 6 (6), 502-510. DOI: 10.7150/jca.11403.

NLM
Liang XX, Li Q, Su Z, Lan XW, Ouyang PY, Mao YP, Shi DB, Deng WG, Cheng ZB, Wang SY, Xie FY. Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma. J Cancer 2015; 6(6):502-510. doi:10.7150/jca.11403. https://www.jcancer.org/v06p0502.htm

CSE
Liang XX, Li Q, Su Z, Lan XW, Ouyang PY, Mao YP, Shi DB, Deng WG, Cheng ZB, Wang SY, Xie FY. 2015. Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma. J Cancer. 6(6):502-510.

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