J Cancer 2019; 10(17):4000-4008. doi:10.7150/jca.29029 This issue
1. Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China;
2. Department of Stomatology, Haikou people's Hospital, Haikou 570208, Hainan, China;
3. Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha 410008, Hunan, China;
4. Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.
Previous studies have revealed that long non-coding RNAs (lncRNAs) are involved in head and neck squamous cell carcinoma (HNSCC) progression. However, the detailed roles of lncRNA RHPN1-AS1 remain to be elucidated. In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade. High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (β-Catenin, Claudin-1 and Vimentin) in HNSCC cells. Collectively, our results suggest that RHPN1-AS1, acting as an oncogene, may be a potential diagnostic and therapeutic target in HNSCC.
Keywords: Long non-coding RNA, RHPN1-AS1, HNSCC, EMT