J Cancer 2019; 10(19):4455-4462. doi:10.7150/jca.34016 This issue

Review

Effect of HPV Infection on the Occurrence and Development of Laryngeal Cancer: A Review

Dongli Yang1,2*, Yong Shi1,2*, Yemei Tang1,2*, Hongyu Yin1,2, Yujia Guo1,2, Shuxin Wen1,2,3, Binquan Wang1,2,3, Changming An4, Yongyan Wu1,2,3✉, Wei Gao1,2,3✉

1. Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China.
2. Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China.
3. The Key Scientific and Technological Innovation Platform for Precision Diagnosis and Treatment of Head and Neck Cancer, Shanxi Province, Taiyuan 030001, Shanxi, China.
4. Department of Head and Neck Surgery, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
*These authors contribute equally.

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Citation:
Yang D, Shi Y, Tang Y, Yin H, Guo Y, Wen S, Wang B, An C, Wu Y, Gao W. Effect of HPV Infection on the Occurrence and Development of Laryngeal Cancer: A Review. J Cancer 2019; 10(19):4455-4462. doi:10.7150/jca.34016. Available from https://www.jcancer.org/v10p4455.htm

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Abstract

Laryngeal cancer has the second highest incidence of head and neck malignant tumors worldwide. In recent years, studies have shown that human papillomavirus (HPV) infection may be a high-risk factor for laryngeal cancer and closely related to the development and prognosis of laryngeal cancer. The mechanism of the occurrence and development of laryngeal cancer caused by HPV infection needs investigation, as does a rapid and effective HPV detection method for effectively preventing the occurrence of laryngeal cancer and controlling its development. Many studies have explored the relation between HPV infection and laryngeal cancer. Here we review the research progress in investigating HPV infection in terms of DNA, mRNA and protein levels in the occurrence and development of laryngeal cancer and routine HPV detection methods.

Keywords: Human Papillomavirus, HPV Testing, Incidence, Head and Neck Carcinoma, Laryngeal Carcinoma