J Cancer 2019; 10(19):4473-4480. doi:10.7150/jca.33368 This issue

Research Paper

POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma

Haoran Ma1*, Lijuan Li1*, Lizhou Jia2, Aixiu Gong1, Aitao Wang3, Lingli Zhang4, Mingyan Gu5✉#, Genxiong Tang1✉#

1. Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China
2. Key Laboratory of Antibody Technique of National Health and Family Planning Commission, Nanjing Medical University, Nanjing, China
3. Department of Anesthesiology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China
4. Department of Ophthalmology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China
5. Department of Stomatology, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
*Haoran Ma and Lijuan Li contributed equally to this work
# Genxiong Tang and Mingyan Gu contributed equally to this study

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Ma H, Li L, Jia L, Gong A, Wang A, Zhang L, Gu M, Tang G. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. J Cancer 2019; 10(19):4473-4480. doi:10.7150/jca.33368. Available from https://www.jcancer.org/v10p4473.htm

File import instruction

Abstract

Background: The aim of this study was to confirm the role of nuclear pore membrane protein 121(POM121) in oral squamous cell carcinoma and to explore the underlying mechanism.

Methods: POM121mRNA and protein expressions were evaluated in OSCC tissues and normal oral tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry. The relationship between POM121 expression and clinical characteristics was analyzed. Bioinformatics analysis was performed to explore the possible mechanisms how POM121 affected OSCC.

Results: We confirmed that POM121 mRNA expression in OSCC tissues was significantly higher than that in non-tumorous tissues, as was POM121 protein expression. POM121 expression was associated with distant metastasis and TNM stage. Multivariate analysis confirmed POM121 expression as an independent prognostic factor for OSCC patients. OSCC patients with high POM121 expression had a worse overall survival (OS) compared with patients with low POM121 expression. Bioinformatics analysis indicated POM121 may regulate OSCC through hedgehog and /or p53 signaling pathway.

Conclusion: Targeting of POM121 expression levels could provide new diagnostic and therapeutic strategies for OSCC patients.

Keywords: POM121, oral squamous cell carcinoma, prognosis, tissue microarrays