J Cancer 2020; 11(5):1104-1114. doi:10.7150/jca.36076 This issue

Research Paper

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Zhang-Qiang Xiang1*, Saber Imani1*, Yue Hu1*, Rui-Lin Ding1*, Hao-Wen Pang1, Yue Chen2, Shao-Zhi Fu1, Fang Xie1, Wen-Feng He1, Qing-Lian Wen1✉

1. Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (Z-QX, SI, YH, R-LD, H-WP, S-ZF, FX, W-FH, Q-LW).
2. Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (YC).
*These authors contributed equally to this work.

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Citation:
Xiang ZQ, Imani S, Hu Y, Ding RL, Pang HW, Chen Y, Fu SZ, Xie F, He WF, Wen QL. Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models. J Cancer 2020; 11(5):1104-1114. doi:10.7150/jca.36076. Available from https://www.jcancer.org/v11p1104.htm

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Abstract

Background: To determine the optimum conditions for diagnosis of nasopharyngeal carcinoma, we established VX2 rabbit model to delineate gross target volume (GTV) in different imaging methods.

Methods: The orthotopic nasopharyngeal carcinoma (NPC) was established in sixteen New Zealand rabbits. After 7-days inoculation, the rabbits were examined by CT scanning and then sacrificed for pathological examination. To achieve the best delineation, different GTVs of CT, MRI, 18F-FDG PET/CT, and 18F-FLT PET/CT images were correlated with pathological GTV (GTVp).

Results: We found 45% and 60% of the maximum standardized uptake value (SUVmax) as the optimal SUV threshold for the target volume of NPC in 18F-FDG PET/CT and 18F-FLT PET/CT images, respectively (GTVFDG45% and GTVFLT60%). Moreover, the GTVMRI and GTVCT were significantly higher than the GTVp (P ≤ 0.05), while the GTVFDG45% and especially GTVFLT60% were similar to the GTVp (R = 0.892 and R = 0.902, respectively; P ≤ 0.001).

Conclusions: Notably, the results suggested that 18F-FLT PET/CT could reflect the tumor boundaries more accurately than 18F-FDG PET/CT, MRI and CT, which makes 18F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC.

Keywords: Nasopharyngeal carcinoma, Gross tumor volume, Magnetic resonance imaging, Computed tomography, 18F-FLT PET/CT, 18F-FDG PET/CT.