Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Xiang, Zhang-Qiang; Imani, Saber; Hu, Yue; Ding, Rui-Lin; Pang, Hao-Wen; Chen, Yue; Fu, Shao-Zhi; Xie, Fang; He, Wen-Feng; Wen, Qing-Lian

doi:10.7150/jca.36076

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J Cancer 2020; 11(5):1104-1114. doi:10.7150/jca.36076 This issue Cite

Research Paper

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Zhang-Qiang Xiang^1*, Saber Imani^1*, Yue Hu^1*, Rui-Lin Ding^1*, Hao-Wen Pang¹, Yue Chen², Shao-Zhi Fu¹, Fang Xie¹, Wen-Feng He¹, Qing-Lian Wen^1✉

1. Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (Z-QX, SI, YH, R-LD, H-WP, S-ZF, FX, W-FH, Q-LW).
2. Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (YC).
*These authors contributed equally to this work.

Citation:

Xiang ZQ, Imani S, Hu Y, Ding RL, Pang HW, Chen Y, Fu SZ, Xie F, He WF, Wen QL. Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models. J Cancer 2020; 11(5):1104-1114. doi:10.7150/jca.36076. https://www.jcancer.org/v11p1104.htm

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Abstract

Background: To determine the optimum conditions for diagnosis of nasopharyngeal carcinoma, we established VX2 rabbit model to delineate gross target volume (GTV) in different imaging methods.

Methods: The orthotopic nasopharyngeal carcinoma (NPC) was established in sixteen New Zealand rabbits. After 7-days inoculation, the rabbits were examined by CT scanning and then sacrificed for pathological examination. To achieve the best delineation, different GTVs of CT, MRI, ¹⁸F-FDG PET/CT, and ¹⁸F-FLT PET/CT images were correlated with pathological GTV (GTVp).

Results: We found 45% and 60% of the maximum standardized uptake value (SUV_max) as the optimal SUV threshold for the target volume of NPC in¹⁸F-FDG PET/CT and ¹⁸F-FLT PET/CT images, respectively (GTV_FDG45% and GTV_FLT60%). Moreover, the GTV_MRI and GTV_CT were significantly higher than the GTVp (P ≤ 0.05), while the GTV_FDG45% and especially GTV_FLT60% were similar to the GTVp (R = 0.892 and R = 0.902, respectively; P ≤ 0.001).

Conclusions: Notably, the results suggested that ¹⁸F-FLT PET/CT could reflect the tumor boundaries more accurately than ¹⁸F-FDG PET/CT, MRI and CT, which makes ¹⁸F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC.

Keywords: Nasopharyngeal carcinoma, Gross tumor volume, Magnetic resonance imaging, Computed tomography, ¹⁸F-FLT PET/CT, ¹⁸F-FDG PET/CT.

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APA

Xiang, Z.Q., Imani, S., Hu, Y., Ding, R.L., Pang, H.W., Chen, Y., Fu, S.Z., Xie, F., He, W.F., Wen, Q.L. (2020). Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models. Journal of Cancer, 11(5), 1104-1114. https://doi.org/10.7150/jca.36076.

ACS

Xiang, Z.Q.; Imani, S.; Hu, Y.; Ding, R.L.; Pang, H.W.; Chen, Y.; Fu, S.Z.; Xie, F.; He, W.F.; Wen, Q.L. Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models. J. Cancer 2020, 11 (5), 1104-1114. DOI: 10.7150/jca.36076.

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CSE

Xiang ZQ, Imani S, Hu Y, Ding RL, Pang HW, Chen Y, Fu SZ, Xie F, He WF, Wen QL. 2020. Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models. J Cancer. 11(5):1104-1114.

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