J Cancer 2020; 11(5):1250-1256. doi:10.7150/jca.37890 This issue Cite

Review

Antitumor functions and mechanisms of nitidine chloride in human cancers

Yue Cui1, Linhui Wu1, Ruoxue Cao1, Hui Xu2, Jun Xia3✉, Z Peter Wang3,4✉, Jia Ma3✉

1. Research Center of Clinical Laboratory Science, School of Laboratory Medicine, Bengbu Medical College, Anhui, China, 233030, China.
2. Department of Laboratory Medicine, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China.
3. Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China.
4. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Citation:
Cui Y, Wu L, Cao R, Xu H, Xia J, Wang ZP, Ma J. Antitumor functions and mechanisms of nitidine chloride in human cancers. J Cancer 2020; 11(5):1250-1256. doi:10.7150/jca.37890. https://www.jcancer.org/v11p1250.htm
Other styles

File import instruction

Abstract

Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients.

Keywords: Nitidine chloride, Cancer, Therapy, Target, Antitumor


Citation styles

APA
Cui, Y., Wu, L., Cao, R., Xu, H., Xia, J., Wang, Z.P., Ma, J. (2020). Antitumor functions and mechanisms of nitidine chloride in human cancers. Journal of Cancer, 11(5), 1250-1256. https://doi.org/10.7150/jca.37890.

ACS
Cui, Y.; Wu, L.; Cao, R.; Xu, H.; Xia, J.; Wang, Z.P.; Ma, J. Antitumor functions and mechanisms of nitidine chloride in human cancers. J. Cancer 2020, 11 (5), 1250-1256. DOI: 10.7150/jca.37890.

NLM
Cui Y, Wu L, Cao R, Xu H, Xia J, Wang ZP, Ma J. Antitumor functions and mechanisms of nitidine chloride in human cancers. J Cancer 2020; 11(5):1250-1256. doi:10.7150/jca.37890. https://www.jcancer.org/v11p1250.htm

CSE
Cui Y, Wu L, Cao R, Xu H, Xia J, Wang ZP, Ma J. 2020. Antitumor functions and mechanisms of nitidine chloride in human cancers. J Cancer. 11(5):1250-1256.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image