J Cancer 2020; 11(23):6970-6981. doi:10.7150/jca.44384 This issue

Review

The functional roles of long noncoding RNA DANCR in Human Cancers

Lei Pan1, Xiudi Xiao1, Yuan Zhao1, Liang Yin1, Min Fu2,3, Xu Zhang2✉, Pengcheng Jiang3✉

1. Department of Breast Surgery, The Affiliated People's Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, Jiangsu 212002, China.
2. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China.
3. Department of General Surgery, The Affiliated People's Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, Jiangsu 212002, China.

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Citation:
Pan L, Xiao X, Zhao Y, Yin L, Fu M, Zhang X, Jiang P. The functional roles of long noncoding RNA DANCR in Human Cancers. J Cancer 2020; 11(23):6970-6981. doi:10.7150/jca.44384. Available from https://www.jcancer.org/v11p6970.htm

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Abstract

Long noncoding RNAs (lncRNAs) have been wildly explored in various cellular processes and their aberrant expression could lead to tumorigenesis, development and progression. Differentiation antagonizing non-protein coding RNA (DANCR), a well-known lncRNA that is aberrant expression in various tumors, including hepatocellular carcinoma, gastric cancer, colorectal cancer, breast cancer, lung cancer and glioma and so on, in which it functions as oncogene mainly, contributing to cancer development and progression. High expressed DANCR is correlated with poor prognosis. In the present review, we summarize recent progression concerning the role, potential clinical utilities and underlying molecular mechanisms of DANCR related to occurrence and development of multiple cancers.

Keywords: long noncoding RNA, DANCR, biomarker, therapeutic target