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Volume 12 (11); 2021

Research Papers

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Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients
Lee Jin Lim, Lay Hiang Ling, Yu Pei Neo, Alexander Y.F. Chung, Brian K.P. Goh, Pierce K.H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K.H. Lim, Samuel S. Chong, London L. P. J. Ooi, Caroline G. Lee
J. Cancer 2021; 12(11): 3098-3113. doi:10.7150/jca.56340
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Describing Treatment Patterns for Elderly Patients with Intrahepatic Cholangiocarcinoma and Predicting Prognosis by a Validated Model: A Population-Based Study
Hanlong Zhu, Kun Ji, Wei Wu, Si Zhao, Jian Zhou, Chunmei Zhang, Ruiyi Tang, Lin Miao
J. Cancer 2021; 12(11): 3114-3125. doi:10.7150/jca.53978
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The natural compound n-butylidenephthalide kills high-grade serous ovarian cancer stem cells by activating intrinsic apoptosis signaling pathways
Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding
J. Cancer 2021; 12(11): 3126-3135. doi:10.7150/jca.51650
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Association Between Smoking And Cancers Among Women: Results From The FRiCaM Multisite Cohort Study
Angelo Giosuè Mezzoiuso, Anna Odone, Carlo Signorelli, Antonio Giampiero Russo
J. Cancer 2021; 12(11): 3136-3144. doi:10.7150/jca.54624
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6
Li Li, Xinyi Tao, Yandong Li, Yong Gao, Qinchuan Li
J. Cancer 2021; 12(11): 3145-3153. doi:10.7150/jca.56097
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN
Jing Huang, Yaqin Zhang, Yuan Xu, Qi Xie, Shuang Wu, Yi Dong, Bing Chen, Yang Xia, Lili Guo, Qun Li, Hao Gu, Wanglai Hu
J. Cancer 2021; 12(11): 3154-3163. doi:10.7150/jca.56186
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Signature of gene aberrant alternative splicing events in pancreatic adenocarcinoma prognosis
Jun Yao, Yu-Chen Tang, Bin Yi, Jian Yang, Yun Chai, Ni Yin, Zi-Xiang Zhang, Yi-Jun Wei, De-Chun Li, Jian Zhou
J. Cancer 2021; 12(11): 3164-3179. doi:10.7150/jca.48661
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study
Ruifeng Liu, Xueliang Zhang, Qiuning Zhang, Hongtao Luo, Shihong Wei, Tingting Liu, Shilong Sun, Zhiqiang Liu, Zheng Li, Jinhui Tian, Xiaohu Wang
J. Cancer 2021; 12(11): 3180-3189. doi:10.7150/jca.50108
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma
Xia Li, Lihong Zhao, Mengke Wei, Jiali Lv, Yawen Sun, Xiaotao Shen, Deli Zhao, Fuzhong Xue, Tao Zhang, Jialin Wang
J. Cancer 2021; 12(11): 3190-3197. doi:10.7150/jca.54429
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer
Tengfei Hao, Jiannan Xu, Sufen Fang, Jianlong Jiang, Xinyuan Chen, Wenhui Wu, Liang Li, Mingzhe Li, Changhua Zhang, Yulong He
J. Cancer 2021; 12(11): 3198-3208. doi:10.7150/jca.55079
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway
Hao Hu, Qi Kong, Xiao-xu Huang, Hao-ran Zhang, Kai-feng Hu, Yan Jing, Yang-fan Jiang, Yue Peng, Long-chao Wu, Qi-sheng Fu, Li Xu, Ya-bin Xia
J. Cancer 2021; 12(11): 3209-3221. doi:10.7150/jca.50403
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeted Sequencing Analysis of Predominant Histological Subtypes in Resected Stage I Invasive Lung Adenocarcinoma
Yan Li, Yan Tan, Song Hu, Jun Xie, Zhantao Yan, Xian Zhang, Yun Zong, Han Han-Zhang, Qing Li, Chong Li
J. Cancer 2021; 12(11): 3222-3229. doi:10.7150/jca.51405
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Clinical diagnostic values of transfer RNA-derived fragment tRF-19-3L7L73JD and its effects on the growth of gastric cancer cells
Yijing Shen, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Qiuyan Wen, Guoliang Ye, Junming Guo
J. Cancer 2021; 12(11): 3230-3238. doi:10.7150/jca.51567
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Increased Expression of KNSTRN in Lung Adenocarcinoma Predicts Poor Prognosis: A Bioinformatics Analysis Based on TCGA Data
Pengbo Deng, Rongrong Zhou, Jinghui Zhang, Liming Cao
J. Cancer 2021; 12(11): 3239-3248. doi:10.7150/jca.51591
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p
Jin Qian, Yingna Xu, Xing Xu, Zhenyu Tao, Yang Luo, Yichang Xu, Yong Zhang, Chunfa Qian
J. Cancer 2021; 12(11): 3249-3256. doi:10.7150/jca.55558
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Oridonin inhibits tumor angiogenesis and induces vessel normalization in experimental colon cancer
Jing Zhou, Yaocheng Li, Xuejing Shi, Shulan Hao, Fupeng Zhang, Zhi Guo, Yu Gao, Hao Guo, Likun Liu
J. Cancer 2021; 12(11): 3257-3264. doi:10.7150/jca.55929
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of an apoptosis-related prognostic gene signature and molecular subtypes of clear cell renal cell carcinoma (ccRCC)
Weimin Zhong, Fengling Zhang, Chaoqun Huang, Yao Lin, Jiyi Huang
J. Cancer 2021; 12(11): 3265-3276. doi:10.7150/jca.51812
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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High expression of TREM2 promotes EMT via the PI3K/AKT pathway in gastric cancer: bioinformatics analysis and experimental verification
Chunmei Li, Xiaoming Hou, Shuqiao Yuan, Yigan Zhang, Wenzhen Yuan, Xiaoguang Liu, Juan Li, Yuping Wang, Quanlin Guan, Yongning Zhou
J. Cancer 2021; 12(11): 3277-3290. doi:10.7150/jca.55077
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA GAS5 inhibits Invasion and Migration of Lung Cancer through influencing EMT process
Lihuan Zhu, Dongsheng Zhou, Tianxing Guo, Wenshu Chen, Yun Ding, Wujing Li, Yangyun Huang, Jianyuan Huang, Xiaojie Pan
J. Cancer 2021; 12(11): 3291-3298. doi:10.7150/jca.56218
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A Novel TNM Classification for Colorectal Cancers based on the Metro-ticket Paradigm
Jun-Peng Pei, Chun-Dong Zhang, Xiang Fu, Yong Ba, Shuai Yue, Zhe-Ming Zhao, Dong-Qiu Dai
J. Cancer 2021; 12(11): 3299-3306. doi:10.7150/jca.55097
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Effect of Multidisciplinary Team Discussion Intervention on the Prognosis of Advanced Colorectal Cancer
Huaqi Zhang, Jishang Yu, Zhewei Wei, Wenhui Wu, Changhua Zhang, Yulong He
J. Cancer 2021; 12(11): 3307-3314. doi:10.7150/jca.56171
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RNA-binding protein YBX1 promotes cell proliferation and invasiveness of nasopharyngeal carcinoma cells via binding to AURKA mRNA
Yuanyuan Ban, Yixin Tan, Xiaoling Li, Xiayu Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Bo Xiang, Mei Yi
J. Cancer 2021; 12(11): 3315-3324. doi:10.7150/jca.56262
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway
Wen-Tao Zhao, Liu-Xin Han, Lin Liu, Bao-Zhen Zeng, Yi Zhang, Liu-Fang Zhao, Hong-Yan Hu, Jia-Wei Xia, Yi-Ze Li, Xu-Dong Xiang, Xiao-Lin Lin, Di Lu, Gao-Feng Li
J. Cancer 2021; 12(11): 3325-3334. doi:10.7150/jca.56426
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cytoreductive Surgery may be beneficial for highly selected patients with Metastatic Gastrointestinal Stromal Tumors receiving Regorafenib facing Local Progression: A Case Controlled Study
Chun-Nan Yeh, Chia-Hsiang Hu, Shang-Yu Wang, Chiao-En Wu, Jen-Shi Chen, Chun-Yi Tsai, Jun-Te Hsu, Ta-Sen Yeh
J. Cancer 2021; 12(11): 3335-3343. doi:10.7150/jca.50324
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The prediction of survival in Gastric Cancer based on a Robust 13-Gene Signature
Guoguang Wang, Tian Zhan, Fan Li, Jian Shen, Xiang Gao, Lei Xu, Yuan Li, Jianping Zhang
J. Cancer 2021; 12(11): 3344-3353. doi:10.7150/jca.49658
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling
Senjie Du, Hongying Li, Fen Lu, Shang Zhang, Jian Tang
J. Cancer 2021; 12(11): 3354-3366. doi:10.7150/jca.54934
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β
Yun-ning Huang, Yuan-yi Xu, Qian Ma, Meng-qi Li, Jia-xin Guo, Xiaofei Wang, Xiu Jin, Jing Shang, Long-xing Jiao
J. Cancer 2021; 12(11): 3367-3377. doi:10.7150/jca.55550
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CFP is a prognostic biomarker and correlated with immune infiltrates in Gastric Cancer and Lung Cancer
Guoliang Cui, Le Geng, Li Zhu, Zhenyan Lin, Xuan Liu, Zhengyue Miao, Jintao Jiang, Xiaoke Feng, Fei Wei
J. Cancer 2021; 12(11): 3378-3390. doi:10.7150/jca.50832
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3
Ruizhen Ren, Yuanna Du, Xing Niu, Rukun Zang
J. Cancer 2021; 12(11): 3393-3406. doi:10.7150/jca.51437
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Commentary

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Rural-urban difference in colorectal cancer mortality
Tomoya Urakawa, Akihiro Saitsu, Jun Watanabe, Kazuhiko Kotani
J. Cancer 2021; 12(11): 3391-3392. doi:10.7150/jca.59434
[Abstract] [Full text] [PDF] [PubMed] [PMC]