J Cancer 2021; 12(15):4552-4560. doi:10.7150/jca.54148
Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis
Department of Gynecology, Cangzhou Central Hospital, Hebei, 061001, China.
Feng J, Gao Fy, Li Yy, Xiao Xy, Xi J. Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis. J Cancer 2021; 12(15):4552-4560. doi:10.7150/jca.54148. Available from https://www.jcancer.org/v12p4552.htm
Mounting evidence indicates that long non-coding RNAs influence the progression of cervical cancer, but the precise function of LINC01503 in the pathogenesis of the disease remains unknown. Here, we found higher levels of LINC01503 in cervical cancer tissues. High LINC01503 expression was associated with enhanced progression of cervical cancer as indicated by advanced FIGO stage, increased metastasis of tumor cells to lymph nodes, and invasion into deeper cervical tissues. LINC01503 inhibition markedly suppressed the invasion and proliferative ability of tumor cells. Mechanistically, LINC01503 was demonstrated to negatively modulate the expression of miR-615-3p in cervical cancer. CCND1 was found to be a target of miR-615-3p. Rescue experiments indicated that LINC01503 inhibition suppressed the invasion and proliferative ability of the tumor cells, a phenomenon that was reversed following miR-615-3p inhibition or CCND1 overexpression. Collectively, these data indicate that LINC01503 enhances the progression of cervical cancer cells via interaction with miR-615-3p/CCND1 axis.
Keywords: cervical cancer, LINC01503, miR-615-3p, CCND1