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J Cancer 2021; 12(17):5125-5135. doi:10.7150/jca.53282 This issue Cite

Research Paper

BZW2/5MP1 acts as a promising target in hepatocellular carcinoma

Guoxiong Li1*, Anqian Lu2*, Anna Chen1,2, Shuang Geng2, Yu Xu2, Xin Chen1, Jin Yang2✉

1. Department of Gastroenterology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. China.
2. Department of Translational Medicine Center, Affiliated Hospital of Hangzhou Normal University, Institute of Hepatology and Metabolic Diseases of Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. China.
* These authors contributed equally to this work.

✉ Corresponding author: Jin Yang, Department of Translational Medicine Center, Affiliated Hospital of Hangzhou Normal University, Institute of Hepatology and Metabolic Diseases of Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. China. Tel. More

Citation:
Li G, Lu A, Chen A, Geng S, Xu Y, Chen X, Yang J. BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. J Cancer 2021; 12(17):5125-5135. doi:10.7150/jca.53282. https://www.jcancer.org/v12p5125.htm
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Abstract

Graphic abstract

Basic leucine zipper and W2 domain 2 (BZW2), also known as 5MP1, is a protein related to translation regulation. Evidence from previous studies indicates that BZW2 is involved in tumorigenesis in several cancers. However, little is known about the role of BZW2 in hepatocellular carcinoma (HCC). In this study, we first analyzed the gene expression profile of BZW2 in multiple HCC datasets. Next, we explored the biological effects of BZW2 in HCC cell lines. BZW2 was overexpressed in different HCC cohorts. Multivariate analysis confirmed that increased BZW2 expression is an independent prognostic indicator of shorter overall survival. BZW2 coexpressed genes were mainly enriched in the biological processes of ribonucleoprotein complex biogenesis, rRNA metabolism, translational initiation, and negative regulation of metabolic processes. BZW2 depletion reduced proliferation, clonality, and invasion and increased apoptosis in MHCC97-H cells. Furthermore, BZW2 overexpression or knockdown enhanced or impaired c-Myc expression, respectively. Overall, these findings identified BZW2 as a biomarker of HCC and provided novel insight that the effect of BZW2 on the translatome is a potential mechanism that promotes HCC progression via the c-Myc pathway.

Keywords: Hepatocellular carcinoma, BZW2, Prognosis, Translation

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APA
Li, G., Lu, A., Chen, A., Geng, S., Xu, Y., Chen, X., Yang, J. (2021). BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. Journal of Cancer, 12(17), 5125-5135. https://doi.org/10.7150/jca.53282.

ACS
Li, G.; Lu, A.; Chen, A.; Geng, S.; Xu, Y.; Chen, X.; Yang, J. BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. J. Cancer 2021, 12 (17), 5125-5135. DOI: 10.7150/jca.53282.

NLM
Li G, Lu A, Chen A, Geng S, Xu Y, Chen X, Yang J. BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. J Cancer 2021; 12(17):5125-5135. doi:10.7150/jca.53282. https://www.jcancer.org/v12p5125.htm

CSE
Li G, Lu A, Chen A, Geng S, Xu Y, Chen X, Yang J. 2021. BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. J Cancer. 12(17):5125-5135.

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