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Volume 12 (17); 2021

Research Papers

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Correlation between tumor location and survival in stage I lung adenocarcinoma and squamous cell carcinoma: a SEER-based study
Junjie Hu, Mengfan Qi, Xinsheng Zhu, Yan Chen, Jie Dai, Jing Zhang, Gening Jiang, Zhonghong Zhang, Peng Zhang
J. Cancer 2021; 12(17): 5076-5085. doi:10.7150/jca.52572
[Abstract] [Full text] [PDF]


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Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
J. Cancer 2021; 12(17): 5086-5098. doi:10.7150/jca.60027
[Abstract] [Full text] [PDF]


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Genomic Profiling of Circulating Tumor DNA from Patients with Extensive-Stage Small Cell Lung Cancer Identifies Potentially Actionable Alterations
Jing Yang, Xiangyun Wang, Jingli Lu, Hui Chen, Xiaochen Zhao, Chan Gao, Yuezong Bai, Qiwen Zhang, Xiaomin Fu, Xiaojian Zhang
J. Cancer 2021; 12(17): 5099-5105. doi:10.7150/jca.55134
[Abstract] [Full text] [PDF]


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6 Circulating miRNAs can be used as Non-invasive Biomarkers for the Detection of Cervical Lesions
Ruoqi Ning, Silu Meng, Lin Wang, Yao Jia, Fangxu Tang, Haiying Sun, Zhi Zhang, Chong Zhang, Xinran Fan, Bing Xiao, Chunhua Yang, Shuang Li
J. Cancer 2021; 12(17): 5106-5113. doi:10.7150/jca.51141
[Abstract] [Full text] [PDF]


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ADNP prompts the cisplatin-resistance of bladder cancer via TGF-β-mediated epithelial-mesenchymal transition (EMT) pathway
Yu Xie, Shuai Zhu, Jinglei Zang, Guanlin Wu, Yuheng Wen, Yu Liang, Ying Long, Weiming Guo, Chuanbing Zang, Xiang Hu, Gang Fan, Shuanglin Xiang, Jian Zhang
J. Cancer 2021; 12(17): 5114-5124. doi:10.7150/jca.58049
[Abstract] [Full text] [PDF]


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BZW2/5MP1 acts as a promising target in hepatocellular carcinoma
Guoxiong Li, Anqian Lu, Anna Chen, Shuang Geng, Yu Xu, Xin Chen, Jin Yang
J. Cancer 2021; 12(17): 5125-5135. doi:10.7150/jca.53282
[Abstract] [Full text] [PDF]


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Methylation of PAX1 gene promoter in the prediction of concurrent chemo-radiotherapy efficacy in cervical cancer
Xuanxuan Li, Xue. Zhou, Manting Zeng, Yangying Zhou, Yu Zhang, Yu-Ligh Liou, Hong Zhu
J. Cancer 2021; 12(17): 5136-5143. doi:10.7150/jca.57460
[Abstract] [Full text] [PDF]


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Identification of Cysteine Protease Inhibitor CST2 as a Potential Biomarker for Colorectal Cancer
Qiurong Xie, Liya Liu, Xiaoping Chen, Ying Cheng, Jiapeng Li, Xiuli Zhang, Nanhui Xu, Yuying Han, Huixin Liu, Lihui Wei, Jun Peng, Aling Shen
J. Cancer 2021; 12(17): 5144-5152. doi:10.7150/jca.53983
[Abstract] [Full text] [PDF]


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Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma
Yanjie Shuai, Yuansheng Duan, Mengqian Zhou, Kai Yue, Dandan Liu, Yan Fang, Yuxuan Wang, Yansheng Wu, Ze Zhang, Xudong Wang
J. Cancer 2021; 12(17): 5153-5163. doi:10.7150/jca.54475
[Abstract] [Full text] [PDF]


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Potentially Overestimated Efficacy of Nanoparticle Albumin-bound Paclitaxel compared with Solvent-based Paclitaxel in Breast Cancer: A Systemic Review and Meta-analysis
Bing-Xue Li, Xin-Jie Chen, Tong-Jing Ding, Yi-Hua Liu, Ting-Ting Ma, Gan-Lin Zhang, Xiao-Min Wang
J. Cancer 2021; 12(17): 5164-5172. doi:10.7150/jca.59794
[Abstract] [Full text] [PDF]


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E2F4 Promotes the Proliferation of Hepatocellular Carcinoma Cells through Upregulation of CDCA3
Junye Liu, Lulu Xia, Shilei Wang, Xuefei Cai, Xiaoli Wu, Chunhong Zou, Baoju Shan, Miao Luo, Deqiang Wang
J. Cancer 2021; 12(17): 5173-5180. doi:10.7150/jca.53708
[Abstract] [Full text] [PDF]


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A novel function for cyclin D1 as a transcriptional role in oncogenesis and tumor development by ChIP-Seq and RNA-Seq
Yudi Xiong, Yuan Wang, Tianqi Li, Xiaoyan Yu, Yangyang Zeng, Guohui Xiao, Fuxiang Zhou, Yunfeng Zhou
J. Cancer 2021; 12(17): 5181-5192. doi:10.7150/jca.52909
[Abstract] [Full text] [PDF]


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Low expression of CDHR1 is an independent unfavorable prognostic factor in glioma
Haiwei Wang, Xinrui Wang, Liangpu Xu, Yingying Lin, Ji Zhang, Hua Cao
J. Cancer 2021; 12(17): 5193-5205. doi:10.7150/jca.59948
[Abstract] [Full text] [PDF]


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EZH2 Exacerbates Breast Cancer by Methylating and Activating STAT3 Directly
Yi Zhao, Zhansheng Hu, Jincheng Li, Tingyan Hu
J. Cancer 2021; 12(17): 5220-5230. doi:10.7150/jca.50675
[Abstract] [Full text] [PDF]


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miR-3187-3p enhances migration and invasion by targeting PER2 in head and neck squamous cell carcinomas
Lei Xiao, Chao Liu, Shuiting Zhang, Yuanzheng Qiu, Donghai Huang, Diekuo Zhang, Huihong Chen, Hang Ling, Yong Liu, Xin Zhang
J. Cancer 2021; 12(17): 5231-5240. doi:10.7150/jca.58593
[Abstract] [Full text] [PDF]


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Antiproliferative, Apoptotic Effects and Suppression of Oxidative Stress of Quercetin against Induced Toxicity in Lung Cancer Cells of Rats: In vitro and In vivo Study
Zhaorigetu, Islam M Farrag, Amany Belal, Manal H. Al Badawi, Alsayed A. Abdelhady, Fawzy M. A. Abou Galala, Abdou El-Sharkawy, Asmaa A. EL-Dahshan, Ahmed B. M. Mehany
J. Cancer 2021; 12(17): 5249-5259. doi:10.7150/jca.52088
[Abstract] [Full text] [PDF]


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External Validation of Six Liver Functional Reserve Models to predict Posthepatectomy Liver Failure after Major Resection for Hepatocellular Carcinoma
Guangmeng Guo, Zhengqing Lei, Xuewu Tang, Weihu Ma, Anfeng Si, Pinghua Yang, Qi Li, Zhimin Geng, Jiahua Zhou, Zhangjun Cheng
J. Cancer 2021; 12(17): 5260-5267. doi:10.7150/jca.58726
[Abstract] [Full text] [PDF]


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Continuing Cetuximab vs Bevacizumab plus chemotherapy after first progression in wild-type KRAS, NRAS and BRAF V600E metastatic colorectal cancer: a randomized phase II trial
Danyang Li, Feng Wang, Shuning Xu, Ke Li, Xiangrui Meng, Yangyang Huang, Ning Ma, Lei Qiao, Gaizhen Kuang, Jinghong Chen, Ying Liu
J. Cancer 2021; 12(17): 5268-5274. doi:10.7150/jca.60014
[Abstract] [Full text] [PDF]


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Analysis of Factors Influencing Relapse and Pregnancy in Patients with Borderline Ovarian Tumors
Ya Qi, Min Wang, Yuwei Yang, Zhi Zeng, Yingying Zhou
J. Cancer 2021; 12(17): 5275-5285. doi:10.7150/jca.56387
[Abstract] [Full text] [PDF]


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Identification of Hub Genes and Small Molecule Drugs Associated with Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer
Guangda Li, Yunfei Ma, Mingwei Yu, Xiaoxiao Li, Xinjie Chen, Yu Gao, Peiyu Cheng, Ganlin Zhang, Xiaomin Wang
J. Cancer 2021; 12(17): 5286-5295. doi:10.7150/jca.56506
[Abstract] [Full text] [PDF]


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MicroRNA-133 Targets Phosphodiesterase 1C in Drosophila and Human Oral Cancer Cells to Regulate Epithelial-Mesenchymal Transition
Ji Eun Jung, Joo Young Lee, Hae Ryoun Park, Ji Wan Kang, Yun Hak Kim, Ji Hye Lee
J. Cancer 2021; 12(17): 5296-5309. doi:10.7150/jca.56138
[Abstract] [Full text] [PDF]


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Trop2 binding IGF2R induces gefitinib resistance in NSCLC by remodeling the tumor microenvironment
Xia Sun, Lizhou Jia, Tengqi Wang, Yulian Zhang, Wei Zhao, Xiangcheng Wang, Hao Chen
J. Cancer 2021; 12(17): 5310-5319. doi:10.7150/jca.57711
[Abstract] [Full text] [PDF]


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Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression
Jun Wang, Runkun Liu, Yufeng Wang, Huanye Mo, Yongshen Niu, Qiuran Xu, Qingguang Liu
J. Cancer 2021; 12(17): 5320-5330. doi:10.7150/jca.58697
[Abstract] [Full text] [PDF]


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Prognostic Value of KRAS Exon 3 and Exon 4 Mutations in Colorectal Cancer Patients
Tianan Guo, Yuchen Wu, Dan Huang, Yutong Jin, Weiqi Sheng, Sanjun Cai, Xiaoyan Zhou, Xiaoli Zhu, Fangqi Liu, Ye Xu
J. Cancer 2021; 12(17): 5331-5337. doi:10.7150/jca.59193
[Abstract] [Full text] [PDF]


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Dyslipidemia in Chinese Pancreatic Cancer Patients: A Two-Center Retrospective Study
Feiyang Wang, Li Huang, Jinyan Zhang, Junwei Fan, Heshui Wu, Junming Xu
J. Cancer 2021; 12(17): 5338-5344. doi:10.7150/jca.60340
[Abstract] [Full text] [PDF]


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FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
J. Cancer 2021; 12(17): 5345-5354. doi:10.7150/jca.60543
[Abstract] [Full text] [PDF]


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Metronomic vinorelbine is an excellent and safe treatment for advanced breast cancer: a retrospective, observational study
Chien-Ting Liu, Meng-Che Hsieh, Yu-Li Su, Chaio-Ming Hung, Sung-Nan Pei, Chun-Kai Liao, Yu-Fen Tsai, Hsiu-Yun Liao, Wei-Ching Liu, Chong-Chi Chiu, Shih-Chung Wu, Shih-Ho Wang, Ching-Ting Wei, Kun-Ming Rau
J. Cancer 2021; 12(17): 5355-5364. doi:10.7150/jca.60682
[Abstract] [Full text] [PDF]


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Discrepancy of Breast and Axillary Pathologic Complete Response and Outcomes in Different Subtypes of Node-positive Breast Cancer after Neoadjuvant Chemotherapy
Shin-Cheh Chen, Chi-Chang Yu, Hsien-Kun Chang, Yung-Chang Lin, Yung-Feng Lo, Shih-Che Shen, Wen-Lin Kuo, Hsiu-Pei Tsai, Hsu-Huan Chou, Chia-Hui Chu, Wen-Chi Shen, Ren-Chin Wu, Shir-Hwa Ueng, Yi-Ting Huang
J. Cancer 2021; 12(17): 5365-5374. doi:10.7150/jca.62830
[Abstract] [Full text] [PDF]

Reviews

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The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers
Meng-Ping Jiang, Wen-Xiu Xu, Jun-Chen Hou, Qi Xu, Dan-Dan Wang, Jin-Hai Tang
J. Cancer 2021; 12(17): 5206-5219. doi:10.7150/jca.58182
[Abstract] [Full text] [PDF]


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Gasdermin E-mediated programmed cell death: An unpaved path to tumor suppression
Yueyuan Wang, Jingyu Peng, Xiao Xie, Zhihao Zhang, Mingxi Li, Ming Yang
J. Cancer 2021; 12(17): 5241-5248. doi:10.7150/jca.48989
[Abstract] [Full text] [PDF]