J Cancer 2021; 12(17):5164-5172. doi:10.7150/jca.59794 This issue

Research Paper

Potentially Overestimated Efficacy of Nanoparticle Albumin-bound Paclitaxel compared with Solvent-based Paclitaxel in Breast Cancer: A Systemic Review and Meta-analysis

Bing-Xue Li1,2, Xin-Jie Chen1,2, Tong-Jing Ding1,2, Yi-Hua Liu2, Ting-Ting Ma1, Gan-Lin Zhang1, Xiao-Min Wang1✉

1. Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23 Gallery Back Street, Dongcheng District, Beijing, 100010, PR China.
2. Beijing University of Chinese Medicine, No.11 East Road, North of the Third Ring, Chaoyang District, 100029, PR China.

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Citation:
Li BX, Chen XJ, Ding TJ, Liu YH, Ma TT, Zhang GL, Wang XM. Potentially Overestimated Efficacy of Nanoparticle Albumin-bound Paclitaxel compared with Solvent-based Paclitaxel in Breast Cancer: A Systemic Review and Meta-analysis. J Cancer 2021; 12(17):5164-5172. doi:10.7150/jca.59794. Available from https://www.jcancer.org/v12p5164.htm

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Abstract

Graphic abstract

Background: Nanoparticle albumin-bound paclitaxel (nab-PTX) has exhibited clinical efficacy in breast cancer treatment, but toxicities can be yielded more at the same time. We did this meta-analysis aiming to unambiguously compare nab-PTX with conventional solvent-based paclitaxel (sb-PTX) in breast cancer patients of all stages.

Method: Pubmed, Embase and Cochrane Library were searched for head-to-head randomized controlled trials of nab-PTX and sb-PTX in breast cancer. Risk ratio (RR) with 95% confidence interval was used for dichotomous variables while Hazard ratio (HR) was used for time-to-event outcomes.

Results: Our review finally included 9 studies with 3508 patients. Nab-PTX showed a benefit on objective response rate (ORR) (RR=1.22 [1.04-1.43], P=0.01) as well as non-inferiority compared with sb-PTX in disease control rate (DCR) (RR=1.01 [0.98-1.04], P=0.44), overall survival (OS) (HR=0.99 [0.93-1.05], P=0.81) and disease free survival/progression free survival (DFS/PFS) (HR=0.92 [0.81-1.05], P=0.21). However, when it comes to toxicities (fatigue, nausea or vomiting, peripheral sensory neuropathy and adverse event related discontinuation), results favored sb-PTX (RR=2.89 [1.07-7.8], 3.15 [1.78-5.59], 2.11 [1.32-3.37], 2.02 [1.61-2.53]; P<0.05). Patients with metastatic tumors or undergoing conventional schedule responses better to nab-PTX than the compared groups (RR of ORR in metastatic vs early or locally advanced patients: 1.46 [1.09-1.96] vs 1.01 [0.94-1.08]; conventional vs dose dense group: 1.59 [1.23-2.06] vs 1.01 [0.91-1.12]).

Conclusions: Nab-PTX can improve ORR compared with paclitaxel and should be given priority to when aiming to reduce tumor load in breast cancer. Sb-PTX of dose dense schedule is recommended when toxicity of nab-PTX is hard to bear for breast cancer patients.

Keywords: breast cancer, nab-paclitaxel, paclitaxel, efficacy, toxicity, meta-analysis