J Cancer 2021; 12(17):5206-5219. doi:10.7150/jca.58182 This issue

Review

The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers

Meng-Ping Jiang#, Wen-Xiu Xu#, Jun-Chen Hou, Qi Xu, Dan-Dan Wang, Jin-Hai Tang

Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
#These authors contributed equally to this article.

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Citation:
Jiang MP, Xu WX, Hou JC, Xu Q, Wang DD, Tang JH. The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers. J Cancer 2021; 12(17):5206-5219. doi:10.7150/jca.58182. Available from https://www.jcancer.org/v12p5206.htm

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Abstract

Graphic abstract

Circular RNAs (circRNAs) are a unique family of noncoding RNAs that could regulate multiple biological processes, which play a crucial role in carcinogenesis, progression and chemotherapy resistance of cancers. Growing studies have demonstrated that circRNAs act as novel biomarkers and therapeutic targets for cancers by sponging microRNAs (miRNAs). Up to date, another function of circRNAs, combining with RNA-binding proteins (RBPs), was uncovered. However, there is limit studies illustrating the underlying mechanism of circRNAs-RBPs interactions, as well as showing its roles in diverse types of cancers. In this review, we collected the biogenesis, properties of circRNAs, and then synthesize the connection between circRNAs and RBPs, and try to clarify its molecular mechanisms involving in the pathogenesis and progression of several common cancers, aiming to provide a brand-new insight to the prognosis and treatment strategy for cancers.

Keywords: circular RNAs (circRNAs), RNA binding proteins (RBPs), biogenesis, transcription, cancers