J Cancer 2021; 12(18):5573-5582. doi:10.7150/jca.56532 This issue


Advances in deubiquitinating enzymes in lung adenocarcinoma

Xi-Jia Zhou1, Rui Li1, Xiao Liu1, Yi-Qing Qu2✉

1. Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University (Jinan 250012, China)
2. Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University (Jinan 250012, China)

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Zhou XJ, Li R, Liu X, Qu YQ. Advances in deubiquitinating enzymes in lung adenocarcinoma. J Cancer 2021; 12(18):5573-5582. doi:10.7150/jca.56532. Available from https://www.jcancer.org/v12p5573.htm

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Graphic abstract

The process of ubiquitination and deubiquitination is widely present in the human body's protein reactions and plays versatile roles in multiple diseases. Deubiquitinating enzymes (DUBs) are significant regulators of this process, which cleave the ubiquitin (Ub) moiety from various substrates and maintain protein stability. Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer (NSCLC) and remains refractory to treatment. To elucidate the mechanism of LUAD and advance new therapeutic targets, we review the latest research progress on DUBs in LUAD. We summarize the biological capabilities of these DUBs and further highlight those DUBs that may serve as anticancer target candidates for precision treatment. We also discuss deubiquitinase inhibitors, which are expected to play a role in targeted LUAD therapy.

Keywords: deubiquitinating enzymes, lung adenocarcinoma, deubiquitinase inhibitor, targeted therapy