J Cancer 2021; 12(24):7320-7325. doi:10.7150/jca.61847 This issue

Research Paper

Prognostic Impact of Preoperative Renal Insufficiency on Metastasis-Free Survival after Radical Cystectomy

Jungyo Suh1, Hyeong Dong Yuk2, Chang Wook Jeong2,3, Cheol Kwak2,3, Hyeon Hoe Kim2,3, Ja Hyeon Ku2,3✉

1. Department of Urology, Asian Medical Centre, Seoul, South Korea.
2. Department of Urology, Seoul National University Hospital, Seoul, South Korea.
3. Department of Urology, Seoul National University College of Medicine, Seoul, South Korea.

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Citation:
Suh J, Yuk HD, Jeong CW, Kwak C, Kim HH, Ku JH. Prognostic Impact of Preoperative Renal Insufficiency on Metastasis-Free Survival after Radical Cystectomy. J Cancer 2021; 12(24):7320-7325. doi:10.7150/jca.61847. Available from https://www.jcancer.org/v12p7320.htm

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Abstract

Graphic abstract

Several studies founded that preoperative renal insufficiency is associated with a higher risk of upper tract urothelial carcinoma recurrence and mortality than normal renal function patients. However, previous studies were all retrospective; no study focused on urothelial carcinoma in the bladder and metastasis-free survival (MFS). Herein, we examined the prognostic impact of preoperative renal insufficiency on the oncologic outcomes of patients with urothelial carcinoma in the bladder after radical cystectomy. We used data from 262 patients prospectively collected from a radical cystectomy cohort between March 2016 and February 2021. The patients were divided into those with a preoperative glomerular filtration rate (GFR) of <60 mL/min/1.73 m2 (renal insufficiency; n=66) and those with a GFR ≥60 mL/min/1.73 m2 (control; n=196). We investigated MFS, cancer-specific survival (CSS), and overall survival (OS). Kaplan-Meier curves and Cox proportional hazard regression were used to estimate the prognostic impact of renal insufficiency. The mean MFS was significantly shorter in the renal insufficiency group than in the control group (36.58±3.09 months vs. 47.37±1.87 months); however, OS and CSS were not significantly different. T stage ≥3 (hazard ratio [HR]: 2.79), lymph node positivity (HR: 2.261), and renal insufficiency (HR: 2.04) were significant independent predictors of MFS. Preoperative renal insufficiency was an independent prognostic factor for worse MFS. Well-designed randomized clinical trials and translational studies are needed to clarify the mechanism of relationship between preoperative renal insufficiency and MFS.

Keywords: bladder cancer, metastasis, radical cystectomy, renal insufficiency, survival, urothelial carcinoma