J Cancer 2021; 12(24):7436-7444. doi:10.7150/jca.62788 This issue

Research Paper

Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia

Yuying Liu1,2*, Yizhong Ge2,3,4*, Qinqin Li1,2,3*, Guotian Ruan2,3, Qi Zhang2,3, Xi Zhang2,3, Meng Tang2,3, Mengmeng Song2,3, Xiaowei Zhang2,3, Xiangrui Li2,3, Kangping Zhang2,3, Ming Yang2,3, Chunlei Hu2,3, Tong Liu2,3, Hailun Xie2,3, Yongbing Chen2,3, Kaiying Yu2,3, Minghua Cong5, Wei Li6, Zhengping Wang1✉, Hanping Shi2,3✉

1. Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
2. Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
3. Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, China.
4. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
5. Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100038, China.
6. Cancer Center, the First Hospital, Jilin University, Changchun, 130021, China.
*Equal contributions to this work with shared first authorship.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Liu Y, Ge Y, Li Q, Ruan G, Zhang Q, Zhang X, Tang M, Song M, Zhang X, Li X, Zhang K, Yang M, Hu C, Liu T, Xie H, Chen Y, Yu K, Cong M, Li W, Wang Z, Shi H. Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia. J Cancer 2021; 12(24):7436-7444. doi:10.7150/jca.62788. Available from https://www.jcancer.org/v12p7436.htm

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Abstract

Graphic abstract

Background: Changes in platelet count (PLT) are strongly associated with patient survival and may be clinically indicative of certain underlying diseases. However, there were few studies on the prognosis of patients with cancer cachexia.

Objective: The purpose of this study was to investigate the relationship between PLT and 1-year survival in patients with cancer cachexia.

Methods: We performed a nested case-control study of data from a multicenter clinical study of cancer. There were 252 patients with cancer cachexia whose survival time was less than or equal to 1 year and 252 patients with cancer cachexia whose survival time was more than 1 year meeting the inclusion criteria. The mortality risk and the adjusted risk were estimated by logistic regression and displayed as odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results: PLT was negatively correlated with 1-year overall survival (OS) of patients with cancer cachexia (increased per standard deviation (SD): OR = 1.29; 95% CI: 1.05-1.60; P = 0.018). The higher the PLT, the lower the OS of patients. When classified by dichotomy (D1 < 296×109/L, D2 ≥ 296×109/L), OS of patients in the D2 group was worse (OR = 2.18; 95% CI: 1.38-3.47; P = 0.001). When classified by quartile (Q1- Q3 < 305×109/L, Q4 ≥ 305×109/L), OS of patients in the Q4 group was poorer (OR = 1.82; 95% CI: 1.14-2.94; P = 0.013). In addition, patients with a low PLT (< 296×109/L) and either a high total bilirubin (TBIL) (≥ 17.1 µmol/L) or a smoking history had poor 1-year survival. Based on our primary cohort study, we conducted a survival analysis of 3130 patients with cancer cachexia and found that OS was better in patients with low PLT (< 296×109/L).

Conclusion: PLT was negatively correlated with 1-year overall survival of patients with cancer cachexia.

Keywords: platelet count, survival, cancer cachexia, nested case-control study