J Cancer 2021; 12(24):7498-7506. doi:10.7150/jca.64833 This issue

Review

Aberrant lipid metabolism in cancer cells and tumor microenvironment: the player rather than bystander in cancer progression and metastasis

Xiujing Yu1#, Shuyi Mi2#, Jun Ye2✉, Guochun Lou2✉

1. Department of Endoscopy Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
2. Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
# These authors contribute equally to this manuscript.

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Citation:
Yu X, Mi S, Ye J, Lou G. Aberrant lipid metabolism in cancer cells and tumor microenvironment: the player rather than bystander in cancer progression and metastasis. J Cancer 2021; 12(24):7498-7506. doi:10.7150/jca.64833. Available from https://www.jcancer.org/v12p7498.htm

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Abstract

Graphic abstract

As the primary cause of cancer-induced fatality and morbidity, cancer metastasis has been a hard nut to crack. Existing studies indicate that lipid metabolism reprogramming occurring in cancer cells and surrounding cells in TME also endows the aggressive and spreading properties with malignant cells. In this review we describe the lipid metabolic reprogramming of cancer cells at different steps along the metastatic process, we also summarize the altered lipid metabolism of non-cancer cells in TME during tumor metastasis. Additionally, we reveal both intrinsic and extrinsic factors which influence the cellular lipid metabolism reprogramming.

Keywords: lipid metabolism remodeling, tumor microenvironment, cancer metastasis, intrinsic factors, extrinsic factors