J Cancer 2022; 13(8):2504-2514. doi:10.7150/jca.71313 This issue

Research Paper

ORC6 acts as a biomarker and reflects poor outcome in clear cell renal cell carcinoma

Qiufeng Pan*, Fuchun Li*, Yi Ding, Haoxuan Huang, Ju Guo

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
* Equal contribution.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Pan Q, Li F, Ding Y, Huang H, Guo J. ORC6 acts as a biomarker and reflects poor outcome in clear cell renal cell carcinoma. J Cancer 2022; 13(8):2504-2514. doi:10.7150/jca.71313. Available from https://www.jcancer.org/v13p2504.htm

File import instruction

Abstract

Graphic abstract

Purpose: To explore the role of ORC6 in clear cell renal cell carcinoma (ccRCC).

Methods: The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database was used to investigate the association between ORC6 expression and clinicopathological parameters. Furthermore, the expression level of ORC6 was determined in human RCC tissues and cell lines by western blot and PCR. Receiver operating characteristics curves and Kaplan-Meier curves were performed to assess the diagnostic and prognostic value of ORC6 in RCC.

Results: High expression of ORC6 predicted shorter overall survival (OS) (P<0.0001) and acted as an independent prognostic factor. ORC6 could distinguish the tumor from the normal patient (area under the curve=0.8827, P<0.0001). The expression of ORC6 was associated with the P53 signaling pathway, cell cycle, and DNA replication.

Conclusion: ORC6 could serve as a useful diagnostic and prognostic biomarker and a potential therapeutic target for ccRCC.

Keywords: ORC6, origin recognition complex, renal cancer, biomarker, prognosis