J Cancer 2022; 13(9):2933-2944. doi:10.7150/jca.71401 This issue

Review

Role and mechanism of miR-211 in human cancer

Lingling Ye1, Fen Wang2, Jinyan Wang2, Hao Wu2, Hui Yang2, Zhaohui Yang2, Haiwei Huang1✉

1. Department of Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, Jiangsu, China; Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
2. Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

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Citation:
Ye L, Wang F, Wang J, Wu H, Yang H, Yang Z, Huang H. Role and mechanism of miR-211 in human cancer. J Cancer 2022; 13(9):2933-2944. doi:10.7150/jca.71401. Available from https://www.jcancer.org/v13p2933.htm

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Abstract

Graphic abstract

MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3ʹ-untranslated region (3ʹ-UTR) of numerous target genes. Emerging evidence indicates that miRNAs play critical roles in tumorigenesis and progression of cancer. Among them, miR-211 has been extensively studied in multiple cancers. The expression of miR-211 significantly varies with cancer types and may be used as a potential prognostic marker for cancer. MiR-211 can regulate multiple biological processes in cancer, including proliferation, apoptosis, metastasis and drug resistance. Additionally, several factors may contribute to the dysregulation of miR-211 in cancer. Consequently, this review aims to discuss the novel findings that highlight latent value of miR-211 in the prognosis assessment and treatment of cancer.