J Cancer 2023; 14(1):50-60. doi:10.7150/jca.78302 This issue Cite

Research Paper

Chemical screening identifies the anticancer properties of Polyporous parvovarius

Yun Haeng Lee1, Minkyeong Kim4, Hyon Jin Park1, Ji Yun Park1, Eun Seon Song1, Haneur Lee1, Gahyun Ko1, Soonkil Ahn1, Hyung Wook Kwon1,2, Youngjoo Byun3, Changmu Kim4✉, Jaehyuk Choi1✉, Joon Tae Park1,2✉

1. Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
2. Convergence Research Center for Insect Vectors, Incheon National University, Incheon 22012, Korea.
3. College of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
4. Microorganism Resources Division, National Institute of Biological Resources, Incheon 22689, Korea.

Citation:
Lee YH, Kim M, Park HJ, Park JY, Song ES, Lee H, Ko G, Ahn S, Kwon HW, Byun Y, Kim C, Choi J, Park JT. Chemical screening identifies the anticancer properties of Polyporous parvovarius. J Cancer 2023; 14(1):50-60. doi:10.7150/jca.78302. https://www.jcancer.org/v14p0050.htm
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Abstract

Graphic abstract

One of the biggest obstacles in cancer treatment is the development of chemoresistance. To overcome this, attempts have been made to screen novel anticancer substances derived from natural products. The purpose of this study is to find new anticancer candidates in the mycelium culture extract of mushrooms belonging to Polyporus. Here, we used a high-throughput screening to find agents capable of inhibiting cancer cell proliferation. The culture extract of Polyporus Parvovarius mycelium in DY medium (pp-DY) was effective. pp-DY inhibited cancer cell proliferation by inducing apoptosis and S-phase arrest. The anticancer property of pp-DY was not only effective against one type of cancer, but also against another type of cancer. Compound fractionation was performed, and the active ingredient exhibiting anticancer effects in pp-DY was identified as 3,4-dihydroxybenzaldehyde (Protocatechualdehyde, PCA). PCA, like pp-DY, inhibited the proliferation of cancer cells by inducing apoptosis and S-phase arrest. Furthermore, unlike conventional anticancer drugs, PCA did not increase the proportion of the side population that plays the most important role in the development of chemoresistance. Taken together, our data revealed the novel mycelium culture extract that exhibited anticancer property, and identified active ingredients that did not activate a proportion of the side population. These novel findings may have clinical applications in the treatment of cancer, particularly chemo-resistant cancer.

Keywords: Polyporus parvovarius, mycelium culture extract, Protocatechualdehyde


Citation styles

APA
Lee, Y.H., Kim, M., Park, H.J., Park, J.Y., Song, E.S., Lee, H., Ko, G., Ahn, S., Kwon, H.W., Byun, Y., Kim, C., Choi, J., Park, J.T. (2023). Chemical screening identifies the anticancer properties of Polyporous parvovarius. Journal of Cancer, 14(1), 50-60. https://doi.org/10.7150/jca.78302.

ACS
Lee, Y.H.; Kim, M.; Park, H.J.; Park, J.Y.; Song, E.S.; Lee, H.; Ko, G.; Ahn, S.; Kwon, H.W.; Byun, Y.; Kim, C.; Choi, J.; Park, J.T. Chemical screening identifies the anticancer properties of Polyporous parvovarius. J. Cancer 2023, 14 (1), 50-60. DOI: 10.7150/jca.78302.

NLM
Lee YH, Kim M, Park HJ, Park JY, Song ES, Lee H, Ko G, Ahn S, Kwon HW, Byun Y, Kim C, Choi J, Park JT. Chemical screening identifies the anticancer properties of Polyporous parvovarius. J Cancer 2023; 14(1):50-60. doi:10.7150/jca.78302. https://www.jcancer.org/v14p0050.htm

CSE
Lee YH, Kim M, Park HJ, Park JY, Song ES, Lee H, Ko G, Ahn S, Kwon HW, Byun Y, Kim C, Choi J, Park JT. 2023. Chemical screening identifies the anticancer properties of Polyporous parvovarius. J Cancer. 14(1):50-60.

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