J Cancer 2023; 14(3):490-504. doi:10.7150/jca.77110 This issue Cite
Research Paper
1. Department of Ilmul Advia (Pharmacology), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006
2. Department of Moalajat (Medicine), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006
3. Transcriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025
4. Mountain Research Centre for Field Crops, Khudwani, Anantnag, 192101, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India, 192102
5. Division of Forest Products & Utilization, Faculty of Forestry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Benhama, Ganderbal, J&K, India 191202
6. Allelopathy Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, India 202002
7. Biochemistry and Pathology Lab, RRIUM, Srinagar, University of Kashmir, J&K, India, 190006
8. Phytochemistry lab, RRIUM, Srinagar, University of Kashmir, J&K, India, 190006
9. SMPU Unit RRIUM, Srinagar, University of Kashmir, J&K, India, 190006
10. Division of Agricultural Statistics, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025
11. Department of Biology, College of Science, Al-Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
12. Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
13. Basic Health Sciences Department, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
14. SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa
15. Department of Biotechnology, University of Kashmir, Srinagar, J&K, India, 190006
16. Department of Medical Lab Technology, Indian Institute of Health and Technology (IIHT), Deoband, Saharanpur, UP, India, 247554
17. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 11451
Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. Matricaria chamomilla L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. Moreover, we analyzed the antioxidant and cytotoxic activity of M. chamomilla (Gul-e Babuna) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of M. chamomilla fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of M. chamomilla flowers could act as good source of natural anti-cancer compounds.
Keywords: Gul-e-Babuna, Anti-cancer, Antioxidant, Saraṭān, Prostate cancer, CFU, DPPH, TLC, phytomedicine