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Volume 16 (2); 2025

Research Papers

Graphic abstract

Ultrasound irradiation in the presence of microbubbles may enhance the antitumor effect of chemotherapeutic agents against bladder cancer
Takehiro Suzuki, Takuma Sato, Ariunbuyan Sukhbaatar, Maya Sakamoto, Shiro Mori, Tetsuya Kodama, Akihiro Ito
J. Cancer 2025; 16(2): 368-381. doi:10.7150/jca.100846
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Graphic abstract

Prognostic Significance of CCDC8 in Bladder Cancer: Insights from Bioinformatics and Immunohistochemical Analysis
Xiaojie Zhao, Xin Yu, Wenge Li, Lei Wang, Xiaodong Weng, Cheng Liu, Xiuheng Liu
J. Cancer 2025; 16(2): 382-397. doi:10.7150/jca.102655
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Graphic abstract

The immediate risk of cancer and its precursor lesions in women with abnormal cervical glandular cytology
Yang Li, Yao Chen, Wanrun Lin, Keyi Chen, Weiguo Lv, Feng Zhou
J. Cancer 2025; 16(2): 398-405. doi:10.7150/jca.99757
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Graphic abstract

Exosomal miR-552-5p Regulates the Role of NK Cells in EMT of Gastric Cancer via the PD-1/PD-L1 Axis
Jingwen Qin, Jinhua Yang, Haopeng Cui, Chunling Feng, Aiqun Liu
J. Cancer 2025; 16(2): 406-416. doi:10.7150/jca.102360
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Graphic abstract

TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis
Jingtian Chen, Wei Wu, Lingxiao Wang, Jingjing Zhang, Xin Che, Liqin Zhai, Zhenxiang Zhao, Yaoping Li
J. Cancer 2025; 16(2): 417-429. doi:10.7150/jca.102931
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Graphic abstract

Genetically Predicted Immune Cell Traits Mediate the Causal Association Between Plasma Metabolites and Colorectal Cancer
Liye Zhu, Qiting Ning, Jiang Xue, Shanpei Huang, Xingmei Chen, Xinze Qiu, Ni Chen, Shengmei Liang, Jiean Huang, Shiquan Liu
J. Cancer 2025; 16(2): 430-444. doi:10.7150/jca.101011
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Graphic abstract

NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT
Zhen Ren, Xiaohan Li, Chun Fu
J. Cancer 2025; 16(2): 445-459. doi:10.7150/jca.100951
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Graphic abstract

A novel EMT-related risk score model for Uveal melanoma based on ZNF667-AS1 and AP005121.1
Fan Yang, Yue Ren, Dongmei Qi, Xi Liu, Jing Xie
J. Cancer 2025; 16(2): 460-469. doi:10.7150/jca.101823
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Graphic abstract

Evaluation of Band Selection for Spectrum-Aided Visual Enhancer (SAVE) for Esophageal Cancer Detection
Yen-Chun Chen, Riya Karmakar, Arvind Mukundan, Chien-Wei Huang, Wei-Chun Weng, Hsiang-Chen Wang
J. Cancer 2025; 16(2): 470-478. doi:10.7150/jca.102759
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Graphic abstract

MiR-196a2 rs11614913 C Allele is Associated with Increased Wilms Tumor Susceptibility in Chinese Children
Ming Luo, Yizhen Wang, Huimin Yin, Chunlei Zhou, Hongting Lu, Haixia Zhou, Shaohua He, Jing He, Jinhong Zhu, Shouhua Zhang
J. Cancer 2025; 16(2): 479-485. doi:10.7150/jca.102801
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Graphic abstract

MicroRNA MTCO3P38 Inhibits the TMOD1/MMP13 Pathway to Alleviate the Progression of Hepatocellular Carcinoma
Ping Wu, Guoyuan Li, Deliang Guo, Tao Guo, Chengwei Chai
J. Cancer 2025; 16(2): 486-495. doi:10.7150/jca.100556
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Graphic abstract

The association between the polymorphism of RAR related orphan receptor beta and the clinical manifestations of oral squamous cell carcinoma
Wei-En Yang, Chiao-Wen Lin, Yi-Tzu Chen, Chun-Wen Su, Chia-Ming Yeh, Chia-Yi Lee, Shun-Fa Yang, Mu-Kuan Chen
J. Cancer 2025; 16(2): 498-505. doi:10.7150/jca.103945
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Graphic abstract

Hybrid Model with Wavelet Decomposition and EfficientNet for Accurate Skin Cancer Classification
Amina Aboulmira, Hamid Hrimech, Mohamed Lachgar, Mohamed Hanine, Carlos Osorio Garcia, Gerardo Mendez Mezquita, Imran Ashraf
J. Cancer 2025; 16(2): 506-520. doi:10.7150/jca.101574
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Graphic abstract

NLRP3 promotes the proliferation and metastasis of colorectal cancer by regulating the S6K1-GLI1 signaling pathway
Si Li, Xuchao Wang, Li Hong, Zirui Zhuang, Pei Yang, Yu Chen, Yizhou Yao, Linhua Jiang, Xinguo Zhu, Bin Wang
J. Cancer 2025; 16(2): 521-532. doi:10.7150/jca.101285
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Single-fraction high-dose-rate brachytherapy as monotherapy for localized prostate cancer: long-term follow-up study based on meta-analysis
Li Xiao, Li-Li Yu, Li-Yuan Zhang, Wei Guo, Li-Xin Liu, Yun-Chuan Sun, Xuan Kan, Kai Zhang
J. Cancer 2025; 16(2): 533-542. doi:10.7150/jca.104279
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Lentinan inhibits melanoma development by regulating the AKT/Nur77/Bcl-2 signaling axis
Xuebin Lai, Yanling Chen, Rongjie Huang, Fukai Zhu, Lanqian Huang, Nan Chen, Guipeng Li, Wenze Hou, Yutian Pan, Gulimiran Alitongbieke
J. Cancer 2025; 16(2): 543-557. doi:10.7150/jca.100863
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Graphic abstract

Impact of Multimorbidity Burden on Mortality Risk among Colon Cancer Survivors
Su-Hung Wang, Mitsuhiro Koseki, Ming‑Jen Sheu, Huang-Lan Li, Ying-Jia Lin, Ching-Chieh Yang, Chung-Han Ho
J. Cancer 2025; 16(2): 558-566. doi:10.7150/jca.103438
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The Genetic Causal Effect of Autoimmune Diseases on pan-Cancers: Evidence from Mendelian Randomization
Yubin Long, Yujun Pan, Houzhi Yang, Xiangbin Wang, Zichao Jiang, Tianwei Sun
J. Cancer 2025; 16(2): 567-576. doi:10.7150/jca.103693
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Graphic abstract

Expressional and prognostic value of TREM1 in ovarian cancer: A comprehensive study based on bioinformatics and clinical analysis validation
Caihong Tang, Dong Ye, Qiong He, Qionghua He, Wenkai Zhou, Liya Lin, Chao Jiang, Da Huang, Jianwei Zhou
J. Cancer 2025; 16(2): 577-589. doi:10.7150/jca.101152
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Graphic abstract

Phosphoenolpyruvate carboxykinase 2 is a promising prognostic biomarker that correlates with peritumoral dendritic cell infiltration in glioblastoma
Li Yi, Cheng Jiang, Peiquan Guo, Wende Zhu, Xiaobing Jiang
J. Cancer 2025; 16(2): 590-602. doi:10.7150/jca.97034
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Random survival forest predicts survival in patients with metastatic laryngeal and hypopharyngeal cancer and the prognostic benefits of surgery and radiotherapy
Yusheng Wang, Chaofan Li, Feilun Yang, Minjie Gong, Jingkun Qu, Ruiping Ma, Zhenzhen Hu, Miao Lou, Xiaoyong Ren, Guoxi Zheng, Yanxia Bai, Ya Zhang, Jin Hou
J. Cancer 2025; 16(2): 603-621. doi:10.7150/jca.103793
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Polymorphisms in the NSUN1 gene and neuroblastoma risk in Chinese children from Jiangsu province
Jiaming Chang, Chunlei Zhou, Wei Jia, Haixia Zhou, Tianyou Yang, Zhuorong Zhang, Haiyan Wu, Yan Zou, Jing He
J. Cancer 2025; 16(2): 622-628. doi:10.7150/jca.103097
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Mitochondrial Gene Scoring System: Predicting Prognosis and Precision Therapy for TACE Non-Response in Hepatocellular Carcinoma Patients
Jian-ying Ma, Wei Wei, Yi-xian Wang, Zhen-yu Zhao, Zhen-yu Xiong, Jie Mei, Wen-ze Wu, Jia-wei Guo
J. Cancer 2025; 16(2): 629-647. doi:10.7150/jca.103946
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Graphic abstract

Cell-type-specific regulators landscape and regulatory mechanisms underlying pyroptosis in uterine corpus endometrial carcinoma
Hongrui Guo, Wufeng Qin, Jinpeng Li, Fucheng Wang, Jiaolin Yang, Yaling Wang, Xinglin Zhang, Yuanyuan Ding, Kaiwen Ting, Xia Li, Jingru Ji, Yanyan Han, Ailing Hui, Huancheng Su, Sanyuan Zhang, Zhe Wang
J. Cancer 2025; 16(2): 660-679. doi:10.7150/jca.100547
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Graphic abstract

Genetically Predicted 3-Methoxytyrosine Mediates the Causal Association between Fibroblast Growth Factor 21 and Glioblastoma Multiforme
Xuan Chen, Lihui Han, Wenzhe Xu
J. Cancer 2025; 16(2): 680-688. doi:10.7150/jca.98035
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Graphic abstract

Machine Learning-based Prognostic Model for Brain Metastasis Patients: Insights from Blood Test Analysis
Ruidan Li, Zheran Liu, Zhigong Wei, Rendong Huang, Yiyan Pei, Jing Yang, Zijian Qin, Huilin Li, Fang Fang, Xingchen Peng
J. Cancer 2025; 16(2): 689-699. doi:10.7150/jca.103847
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Review

Graphic abstract

Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics
Wanrou Jiang, Yongjun Wu, Xiuyun He, Ling Jiang, Wanyi Zhang, Wenjuan Zheng, Min Hu, Chaofu Zhu
J. Cancer 2025; 16(2): 648-659. doi:10.7150/jca.99421
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Erratum

DGCR5 Promotes Gallbladder Cancer by Sponging MiR-3619-5p via MEK/ERK1/2 and JNK/p38 MAPK Pathways: Erratum
Shilei Liu, Bingfeng Chu, Chen Cai, Xiangsong Wu, Wenyan Yao, Ziyou Wu, Ziyi Yang, Fengnan Li, Yingbin Liu, Ping Dong, Wei Gong
J. Cancer 2025; 16(2): 496-497. doi:10.7150/jca.106439
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